histoplasmosis Correct Answer: SE US, mid Atlantic, central US, caves. Acute PNA, but usually
asymptomatic. HIV disseminated infection- hilar LAD, pneumonitis, pancytopenia, hepatosplenomegaly,
palatal ulcers. tx- IV amphotericin B followed by lifelong itraconazole.
Blastomycosis Correct Answer: central US (most in Wisconsin). Often asymptomatic or flu-like Sx.
Systemic disease- lytic bone lesions, pulmonary infection, skin lesions. Dx- broad-based budding yeast.
Tx- itraconazole, amphotericin B
aspergillosis Correct Answer: invasive in IMCD. CXR - cavitary lesions. CT - pulm nodules, halo sign, air
crescent
sporotrichosis Correct Answer: subcutaneous infection. Gardeners. Travel up lymphatics for nodules on
forearms
cryptococcus Correct Answer: pulm infection often asymptomatic. Usually meningoencephalitis in HIV
with CD4<200
osteogenesis imperfecta Correct Answer: autosomal dominant. Type 1 collagen problem. Type 2 most
severe with perinatal fractures and often intrauterine death. Blue sclera, fractures, hypotonia, hearing
loss, joint hypermobility, dentinogenesis imperfecta
polymyalgia rheumatica Correct Answer: neck/shoulder/hip pain/stiffness. >50 years old, high ESR. Tx-
low dose prednisone, high dose for temporal arteritis
massive blood transfusion Correct Answer: citrate anticoagulant --> chelates Ca and Mg --> low Ca -->
paresthesias, hyperactive reflexes
nephrotic syndrome Correct Answer: dyslipidemia, accelerated atherosclerosis, hypercoagulable, risk
for MI/stroke, higher infxn susceptibility. Can have renal vein thrombosis, usually with membranous GN
aortic regurgitation Correct Answer: early diastolic (mild) to holodiastolic (severe) murmur. Bounding
pulses. Tx- decrease afterload with DHP Ca-channel blockers, ACEi, NOT beta blockers.
mycoplasma PNA Correct Answer: erythema multiforme. No cell wall so not on gram stain
candidal vulvovaginitis Correct Answer: pseudohyphae. In IMCD and Abx treated people. Tx- oral
fluconazole, topical nystatin
nonseminomatous germ cell tumor Correct Answer: large anterior mediastinal mass, young males. High
HCG and AFP.
seminoma Correct Answer: high HCG but normal AFP
thymoma Correct Answer: associated with myasthenia gravis, pemphigus
hepatocellular carcinoma Correct Answer: high AFP but normal HCG
choriocarcinoma Correct Answer: gestational trophoblastic disease usually in molar pregnancy. Very
high HCG
C. dif diagnosis Correct Answer: cytotoxin assay of stool
Jarisch-Herxheimer rxn Correct Answer: primary/secondary syphilis treated with penicillin -->
spirochetes die --> immune complexes --> looks like syphilis flare-up
INH SE Correct Answer: hepatitis, peripheral neuropathy/ataxia (give pyridoxine)
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