100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Summary Importance of Allopurinol in CABG $10.99   Add to cart

Summary

Summary Importance of Allopurinol in CABG

 1 view  0 purchase
  • Course
  • Institution

Importance of Allopurinol in coronary artery bypass grafting surgery

Preview 1 out of 3  pages

  • July 17, 2022
  • 3
  • 2018/2019
  • Summary
avatar-seller
IMPORTANCE OF ALLOPURINOL IN CABG SURGERY


INTRODUCTION


⚫ Ischemia/reperfusion injury during routine bypass grafting results in a
measurable depression in early postoperative cardiac function
(myocardial stunning) in up to 50% of patients.
⚫ Myocardial stunning is widely held to result from the unchecked free
radical activity and to be amenable to anti-free radical interventions.
⚫ Oxygen-derived free radicals constitute one major part of the
etiologic factors for cardiac onset harmful events.
⚫ Allopurinol in combination with Vitamin E and C is able to reduce
the generation of free radicals.
⚫ The xanthine oxidase inhibitor allopurinol has been suggested to have
pleiotropic effects that are likely to reduce the incidence of
myocardial infarction (MI) in individuals at risk.
⚫ Xanthine oxidase inhibition exerts its beneficial effects by reducing
the level of free radical activity associated with reperfusion during
coronary artery bypass grafting


Why is a free radical scavenger necessary for patients ungergoing
Coronary Artery Bypass Graft surgery?
➢ Oxidative injury in CABG surgery is integral to ischemia-reperfusion
of the myocardium.
➢ Coronary artery bypass can initiate a systemic inflammatory response
from blood contact with extracorporeal surfaces.
➢ Besides the release of various stress hormones, cytokines and
chemokines, etc., it causes the release of reactive oxygen species
(ROS).
➢ These mediators may cause consumptive coagulopathy, interstitial
fluid shifts, generate a host of microemboli and result in temporary
dysfunction of nearly every organ.

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller aishwaryasuresh. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $10.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

77254 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$10.99
  • (0)
  Add to cart