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MN 553 Pharmacology UNIT 2 QUESTIONS AND ANSWERS(Pharmacology UNIT 2)
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MN 553 Pharmacology UNIT 2 QUESTIONS AND ANSWERS(Pharmacology UNIT 2)
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MN 553 Pharmacology UNIT 2Pathways for drugs Correct Answer: Direct Penetration, Passage through protein channels, Carrier
proteins
Passive Diffusion Correct Answer: The movement of substances into or out of cells without the
expenditure of energy or the involvement of transport proteins in the cell membrane. Also called simple
diffusion.
Facilitated Diffusion Correct Answer: the transport of substances through a cell membrane along a
concentration gradient with the aid of carrier proteins
Active Transport Correct Answer: transport of a substance (as a protein or drug) across a cell membrane
against the concentration gradient, low concentration to high
Pharmacokinetics Correct Answer: The study of the movement of drugs within the body
Absorption Correct Answer: the rate and extent that a drug leaves the site of administration and enters
the blood stream
What factors effect drug absorption Correct Answer: dosage, concentration, solubility, blood flow,
contact time with absorption site, presence of food
Bioavailabilty Correct Answer: amount of drug that is able to reach the target site to produce its effects
First Pass Effect Correct Answer: Drug metabolized by the liver before it's able to reach systemic
circulation
Distribution Correct Answer: The transport of a drug within body fluids to body tissues
Free Drug Correct Answer: Drugs not bound to plasma proteins, drug available in blood stream to act on
body cells
Drug distribution can be affected by.. Correct Answer: Blood flow, Blood Brain Barrier, Placental Barrier,
Protein Binding
Metabolism Correct Answer: Method of changing a drug to be more easily excreted, The body attempts
to neutralize or detoxify substances for excretion, changing fat soluble drugs into water soluble
metabolites that can be excreted from the kidney.
Induction Correct Answer: Stimulation of increased enzyme production, results in more drug being
metabolize= less drug
Inhibition Correct Answer: Competition for limited amount of enzyme, results in less drug
metabolized=more drug
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