NR566 Final (Advanced Pharmacology for Care of the Family)with complete solutions
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Course
NR566
Institution
NR566
Anti-Androgens
Finasteride (Propecia)
Leuprolide (Eligard, Lupron, Lupron Depot)
Spironolactone (Aldactone)
Finasteride (Propecia, Proscar)
blocks conversion of testosterone to dihydrotesterone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see benefits
Stopping...
nr566 final advanced pharmacology for care of the familywith complete solutions
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NR566 Final (Advanced Pharmacology
for Care of the Family)
Anti-Androgens - Answer Finasteride (Propecia)
Leuprolide (Eligard, Lupron, Lupron Depot)
Spironolactone (Aldactone)
Finasteride (Propecia, Proscar) - Answer blocks conversion of testosterone to
dihydrotesterone
Used to tx:
-BPH
-male pattern baldness
3 months of therapy need to see benefits
Stopping, reverses effect w/in 12 months
Adverse side effects:
- Decreased libido
-Impotence
dutasteride (Avodart) - Answer 5-alpha reductase inhibitor
used to tx:
BPH
Can stay in serum up to 6 mon after discontinuing
can be absorbed through skin
pregnant woman shouldn't handle capsules
(fetal anomaly in male fetus)
Adverse Effects
decreased libido
Impotence
Leuprolide Acetate (Lupron) - Answer Luteinizing hormone - releasing agonist
create reversible:
-orchiectomy state
-oophorectomy state
Used to tx:
- advanced prostatic cancer
- Management of endometriosis
- Uterine fibroids
- polycystic ovarian disease
- central precocious puberty in peds
used for tx:
-female hirsutism (abnormal growth of hair)
-acne
-relief of PMS/PMDD symptoms (25-50 mg/d)
Adverse reactions
- dose related + reversible when discont.
-GI upset
-Drowsiness
-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions
- Urticaria
Black Box Warning
Tumorigenicity in animals
Should not be used during pregnancy
Androgen - Answer Testosterone
most important adrogen in humans
levels remain stable at 55yr
70 yrs men decrease in
-strength, libido, muscle mass
Transdermal application of testosterone - Answer Patch + gel
can be applied to intact nonscrotal skin
once daily
not for use in woman
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