, CHEM 361B CHEM MOLECULAR-
ARCHITECTURE-IN-MUSCLE-CONTRACTILE-
A_2005_ADVANCES-IN-PROTEIN-CHEM
1950s and 1960s saw the determination of a variety
of unknown molecular structures using an array of
then novel techniques. The double helix of DNA was
solved using high‐angle X‐ray fiber diffraction data
(Watson and Crick, 1953; Wilkins et al., 1953). The
technique of protein crystallography came of age
when structures of key globular proteins were
determined for the first time (Kendrew, 1963;
Muirhead and Perutz, 1963). At the same time,
electron microscopy and low‐angle X‐ray fiber
diffraction helped to define the
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