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NR566 Week 6 Discussion (Answered with well Discussed)

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NR566 Week 6 Discussion (Answered with well Discussed) 1. A patient returns to the office 3 weeks after starting a new antidepressant medication. She tells the NP, “I’ve been taking it every day like I’m supposed to and I don’t feel any different. I don’t think it’s working.” What...

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  • April 8, 2022
  • April 8, 2022
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  • 2022/2023
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NR566 Week 6 Discussion (Answered with well Discussed)
Week 6 Discussion Post Quiz Answers

1. A patient returns to the office 3 weeks after starting a new antidepressant medication.

She tells the NP, “I’ve been taking it every day like I’m supposed to and I don’t feel any

different. I don’t think it’s working.” What would be the appropriate response?

a) “You might need a higher dose. Let’s double the daily dosage and see what

happens.”

b) “Maybe a different antidepressant would work for you. We will try a new

medication.”

c) “It can take several weeks and up to 2 months to see an effect. Keep taking it

and we will schedule a follow-up appointment in 1 month.”

d) “If the medication is not working, then you might not have clinical depression.”



Most antipsychotics and antidepressants must be taken for several weeks and up to 2

months before the full therapeutic effects are noted. Despite advanced research and medical

knowledge, the exact relationship between the mechanism of action and the resulting effects is

not completely understood, though there are plausible hypotheses based upon the scientific

data that is known. The desired therapeutic effects are thought to be attributed to adaptive

changes that occur in the brain after prolonged drug exposure. The delay in noted therapeutic

effects occurs after the central nervous system has made those adaptive modifications in

response to prolonged medication exposure (Rosenthal & Burchum, 2021, pp. 125-126).

2. Match each medication used in the treatment of Parkinson Disease to its mechanism

of action:

, o Levodopa/carbidopa: Undergoes conversion to DA in the brain and then

activates DA receptors

o Ropinirole: Directly activate DA receptors

o Entacapone: Inhibit breakdown of levodopa by COMT

o Selegiline: Inhibit breakdown of DA by MAO-B

o Amantadine: Promotes release of DA from remaining DA neurons; may also

block DA reuptake



Levodopa/carbidopa is an example of a dopamine replacement combination used to

treat Parkinson Disease symptoms. It is used as a first-line drug or as a supplement in

combination with a dopamine agonist. It reduces the symptoms of this condition by increasing

dopamine synthesis (Rosenthal & Burchum, 2021, p. 129).

Ropinirole is an example of a nonergot derivative dopamine agonist used as a first-line

drug for Parkinson Disease or as a supplement to levodopa. Beneficial effects are a result of the

direct activation of dopamine receptors (Rosenthal & Burchum, 2021, p. 137).

Entacapone is an example of a catechol-O-methyltransferase (COMT) inhibitor used as

an adjunct to levodopa to decrease “wearing off”. Benefits result from inhibiting the

metabolism of levodopa in the periphery and therefore it has no beneficial use except when

combined with levodopa (Rosenthal & Burchum, 2021, p. 138).

Selegiline is an example of a monoamine oxidase-B (MAO-B) inhibitor used in patients

newly diagnosed with Parkinson Disease and for managing “off” times during levodopa therapy.

Its therapeutic effect results from the selective and irreversible inhibition of MAO-B, which is

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