NR507 Week 7 Quiz Study Guide - 09-02-19 ENDOCRINE
2 views 0 purchase
Course
NR507
Institution
NR507
NR507 Week 7 Quiz Study Guide - 09-02-19
WEEK 7 QUIZ STUDY GUIDE ENDOCRINE
• Diabetes Insipidus (DI)
o Disorder of posterior pituitary
o Insufficiency of ADH leading to polyuria and polydipsia
o Nephrogenic DI- caused by inadequate response of renal tubules to ADH (vasopressin) and inabili...
nr507 week 7 quiz study guide 09 02 19 week 7 quiz study guide endocrine • diabetes insipidus di o disorder of posterior pituitary o insufficiency of adh leading to polyuria and polydipsia o neph
Written for
NR507
All documents for this subject (357)
Seller
Follow
ACADEMICAIDSTORE
Reviews received
Content preview
NR507 Week 7 Quiz Study Guide - 09-02-19
WEEK 7 QUIZ STUDY
GUIDE ENDOCRINE
• Diabetes Insipidus (DI)
o Disorder of posterior pituitary
o Insufficiency of ADH leading to polyuria and polydipsia
o Nephrogenic DI- caused by inadequate response of renal tubules to
ADH (vasopressin) and inability to reabsorb filtered H20 back into the
body
o Usually acquired but can be genetic
o Acquired is r/t disorders and drugs that damage renal tubules- pyelonephritis,
amyloidosis, destructive uropathies, polycystic disease, intrinsic renal dx, all
lead to irreversible DI
o Drugs that induce reversible form= lithium, colchicines, loop diuretics, general
anesthetics
o Total inability to concentrate urine
o Insufficient ADH activity causes excretion of large volumes of dilute urine
increased plasma osmolality thirst mechanism is stimulated induces
polydipsia
o Dehydration develops rapidly without fluid replacement
o Criteria for diagnosis includes- polyuria, polydipsia, low urine specific gravity
and osmolality, hypernatremia, high serum osmolality, continued diuresis
Type 1 DM (T1DM)
• Most common pediatric chronic disease
• Can be autoimmune or nonimmune (idiopathic)
• Autoimmune Pathophys-Environmental-genetic factors (infections, cow’s milk
proteins, lack of Vit D, vaccinations, stress) are thought to trigger cell-mediated
destruction of pancreatic beta cells absolute insulin deficiency
o Loss of tolerance to self-antigens with formation of autoantigens expressed on
surface of pancreatic beta cells and circulate in blood and lymph
o Cellular immunity (T-cytotoxic cells and macrophages) and humoral
immunity (autoantibodies) are stimulated resulting in beta-cell destruction and
apoptosis
• Nonimmune Pathophys- far less common does not have an autoimmune basis for
beta- cell destruction, occurs secondary to other diseases (pancreatitis), mostly Asian
and
African descent. Varying degrees of insulin deficiency
• S/S- glucose in urine d/t renal threshold of glucose is exceeded
o Osmotic diuresis manifested as polyuria and polydipsia
o Wide fluctuations in BGL
o Protein and fat breakdown occurs because of lack of insulin weight loss
o Increased hepatic metabolism of fat leads to high levels of circulating ketones
causing DKA
• Diagnosis includes A1C > 6.5%
o FPG >126
o 2 hr plasma glucose > 200
This study source was downloaded by 100000834306259 from CourseHero.com on 02-14-2022 04:08:43 GMT -06:00
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ACADEMICAIDSTORE. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.00. You're not tied to anything after your purchase.
