Carbamazepine has a black box warning recommending testing for the HLA-
B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
Decreased effectiveness of carbamazepine in treating seizures in Asian
patients with the HLA-B*1502 allele
Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele
Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502
allele
Patients who have the HLA-B*1502 allele being more likely to have a resistance to
carbamazepine
Question 2. Question :
Common OTC pain relievers such as acetaminophen or ibuprofen:
, Are always safer for the patient than prescription pain medication
Are harmful if taken in higher-than-recommended amounts
Have minimal interaction with prescription medications
Should never be given to children unless recommended by their provider
Question 3. Question :
Factors that affect gastric drug absorption include:
Liver enzyme activity
Protein-binding properties of the drug molecule
Lipid solubility of the drug
Ability to chew and swallow
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