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DOAC (Direct oral anticoagulants) Test Bundle
DOAC (Direct oral anticoagulants) Test Bundle
[Show more]DOAC (Direct oral anticoagulants) Test Bundle
[Show more]Dabigatran (Pradaxa) Dosing - Answer *Treatment of DVT/PE:* 150 mg BID after 5-10 days of parenteral therapy 
 
 
*VTE Prophylaxis:* 
Total hip - 110 mg once 1-4 hours after surgery and hemostasis then 220 mg once daily for 10-35 days 
 
*Nonvalvular A fib:* 
150 mg BID 
 
Dabigatran (Pradaxa) D...
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Add to cartDabigatran (Pradaxa) Dosing - Answer *Treatment of DVT/PE:* 150 mg BID after 5-10 days of parenteral therapy 
 
 
*VTE Prophylaxis:* 
Total hip - 110 mg once 1-4 hours after surgery and hemostasis then 220 mg once daily for 10-35 days 
 
*Nonvalvular A fib:* 
150 mg BID 
 
Dabigatran (Pradaxa) D...
DOACs: Meds 
DOACs: Newest class of anti-coags 
 
-Direct Thrombin Inhibitor 
 
1. DabigaTran 
 
- Factor Xa inhibitors 
 
1. ApiXaban (Eliquis) 
 
2. BetriXaban (Bevyxxa) 
 
3. EdoXaban (Savaysa) 
 
4. RivaroXaban (Xarelto)
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Add to cartDOACs: Meds 
DOACs: Newest class of anti-coags 
 
-Direct Thrombin Inhibitor 
 
1. DabigaTran 
 
- Factor Xa inhibitors 
 
1. ApiXaban (Eliquis) 
 
2. BetriXaban (Bevyxxa) 
 
3. EdoXaban (Savaysa) 
 
4. RivaroXaban (Xarelto)
Limitations of warfarin - Answer Requires routine INR monitoring 
Frequent dose adjustments 
Has many interactions 
Delayed onset - often requiring concomitant parenteral anticoagulant 
 
Benefits of warfarin - Answer Established monitoring assay (can establish if patient is under or over coa...
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Add to cartLimitations of warfarin - Answer Requires routine INR monitoring 
Frequent dose adjustments 
Has many interactions 
Delayed onset - often requiring concomitant parenteral anticoagulant 
 
Benefits of warfarin - Answer Established monitoring assay (can establish if patient is under or over coa...
DOACs that are factor Xa inhibitors - Answer Rivaroxaban 
Apixaban 
Edoxaban 
 
DOAC that is a direct thrombin inhibitor - Answer Dabigatran 
 
What indication do all DOACs share? - Answer Reduce risk of stroke in nonvalvular atrial fibrillation 
 
Dabigatran Indications - Answer Reduce risk...
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Add to cartDOACs that are factor Xa inhibitors - Answer Rivaroxaban 
Apixaban 
Edoxaban 
 
DOAC that is a direct thrombin inhibitor - Answer Dabigatran 
 
What indication do all DOACs share? - Answer Reduce risk of stroke in nonvalvular atrial fibrillation 
 
Dabigatran Indications - Answer Reduce risk...
MOA - Answer Directly blocks Xa and thrombin (works immediately) 
 
Drug: Dabigatran (direct thrombin inhibitor) - Answer Pradaxa 
 
Drug: Rivaroxaban (direct factor Xa inhibitor) - Answer Xarelto 
 
Drug: Apixaban (direct factor Xa inhibitor) - Answer Eliquis 
 
Drug: Edoxaban (direct facto...
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Add to cartMOA - Answer Directly blocks Xa and thrombin (works immediately) 
 
Drug: Dabigatran (direct thrombin inhibitor) - Answer Pradaxa 
 
Drug: Rivaroxaban (direct factor Xa inhibitor) - Answer Xarelto 
 
Drug: Apixaban (direct factor Xa inhibitor) - Answer Eliquis 
 
Drug: Edoxaban (direct facto...
MOA of DOACs - Answer direct factor Xa inhibitor 
 
MOA of dabigatran - Answer direct thrombin inhibitor 
 
dosing of dabigatran for VTE - Answer usual: 150 mg PO BID after 5-10 days of injectable anticoagulant 
 
renal: contraindicated if CrCl <30 ml/min 
 
monitoring for dabigatran - Ans...
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Add to cartMOA of DOACs - Answer direct factor Xa inhibitor 
 
MOA of dabigatran - Answer direct thrombin inhibitor 
 
dosing of dabigatran for VTE - Answer usual: 150 mg PO BID after 5-10 days of injectable anticoagulant 
 
renal: contraindicated if CrCl <30 ml/min 
 
monitoring for dabigatran - Ans...
Based on the readings, which DOAC has the shortest half-life yet is dosed once daily? 
A. Apixaban 
B. Rivaroxaban 
C. Dabigatran 
 
 
C 
All the DOACs have a short onset of action; however, which two require "bridging" with a parenteral anticoagulant for the treatment of DVT/PE? 
A. Dabigatran an...
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Add to cartBased on the readings, which DOAC has the shortest half-life yet is dosed once daily? 
A. Apixaban 
B. Rivaroxaban 
C. Dabigatran 
 
 
C 
All the DOACs have a short onset of action; however, which two require "bridging" with a parenteral anticoagulant for the treatment of DVT/PE? 
A. Dabigatran an...
What are DOACs used for? - Answer - VTE treatment and prophylaxis 
- stroke prevention (non-valvular a fib) 
- CAD and PAD 
 
What advantages does DOACs have over warfarin? - Answer - fixed dosing 
- predictable 
- quick onset 
- minimal drug-food/drug interactions 
- less monitoring 
-wide TR ...
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Add to cartWhat are DOACs used for? - Answer - VTE treatment and prophylaxis 
- stroke prevention (non-valvular a fib) 
- CAD and PAD 
 
What advantages does DOACs have over warfarin? - Answer - fixed dosing 
- predictable 
- quick onset 
- minimal drug-food/drug interactions 
- less monitoring 
-wide TR ...
Direct Oral Anticoagulants are a drug class that....? - Answer Directly binds to and inhibits clotting factors IIa (thrombin) or Xa 
 
What is unique about Dabigatran compared to the other 4 DOACs? - Answer Only direct thrombin inhibitor 
 
Which DOACs cannot be crushed? - Answer -Dabigatra...
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Add to cartDirect Oral Anticoagulants are a drug class that....? - Answer Directly binds to and inhibits clotting factors IIa (thrombin) or Xa 
 
What is unique about Dabigatran compared to the other 4 DOACs? - Answer Only direct thrombin inhibitor 
 
Which DOACs cannot be crushed? - Answer -Dabigatra...
T/F Anticoagulants dissolve/breakdown clots - Answer false! only prevent clots from forming and keep existing clots from getting larger 
 
Anticoagulant uses - Answer ACS 
prevention of cardioembolic stroke 
prevention/treatment of VTE (DVT and/or PE) 
 
 
Warfarin inhibits which factors? - An...
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Add to cartT/F Anticoagulants dissolve/breakdown clots - Answer false! only prevent clots from forming and keep existing clots from getting larger 
 
Anticoagulant uses - Answer ACS 
prevention of cardioembolic stroke 
prevention/treatment of VTE (DVT and/or PE) 
 
 
Warfarin inhibits which factors? - An...
Following Up on DOACs: 
Checklist - Answer - Compliance: check adherence and educate on importance 
- Thromboembolism: check for recurrence of clotting 
- Bleeding: educate on bleed prevention and management 
- Other ADRs: no many 
- Co-Medications: check for DDIs 
Blood Sampling: renal & hepatic F...
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Add to cartFollowing Up on DOACs: 
Checklist - Answer - Compliance: check adherence and educate on importance 
- Thromboembolism: check for recurrence of clotting 
- Bleeding: educate on bleed prevention and management 
- Other ADRs: no many 
- Co-Medications: check for DDIs 
Blood Sampling: renal & hepatic F...
What are the new oral anticoagulants? - Answer target specific oral anticoagulants: TSOACs 
new oral anticoagulants: NOACs 
direct oral anticoagulants: DOACs 
 
what are disadvantages of vitamin k antagonists - Answer requires bridging due to delay of onset of action 
narrow therapeutic index ...
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Add to cartWhat are the new oral anticoagulants? - Answer target specific oral anticoagulants: TSOACs 
new oral anticoagulants: NOACs 
direct oral anticoagulants: DOACs 
 
what are disadvantages of vitamin k antagonists - Answer requires bridging due to delay of onset of action 
narrow therapeutic index ...
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