Cftr - Study guides, Class notes & Summaries

PATHOLOGY HIGH YIELD NBME ELABORATED QUESTIONS AND REVIEWED ANSWERS 2023/2024 Anticentromere antibodies - CORRECT ANSWER-Scleroderma (CREST) Antidesmoglein (epithelial) antibodies - CORRECT ANSWER-Pemphigus vulgaris (blistering) Anti-glomerular basement membrane antibodies - CORRECT ANSWER-Goodpasture's syndrome (glomerulonehpritis and hemoptysis) Antihistone antibodies - CORRECT ANSWER-Drug-induced SLE (hydralazine, isoniazid, phenytoin, procainamide) Anti-IgG antibodies - CORREC...

NBME CBSE ACTUAL TEST QUESTIONS AND ANSWERS 2024(COMPLETE) (Quiz bank with all the correct answers) (USMLE step 1)Medical examination NBME CBSE ACTUAL TEST 2024 62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial effect of the drug is due to which of the following? Decreased Osteoclast Activity Cohot Study of elderly women – relative risk ratio for hip fractures among those who exercise regularly is 1.2 (95% confidence interval of 1.1 to ...

Module 3 - ENaC and CFTR trafficking and pathophysiology - L19-26 Questions With Complete Solutions

CPPS 325 - CFTR Do mutations in CFTR modulate membrane lipids Exam...

GCD Final Test Questions with Complete Solutions Cell theory is the idea that - Answer-all living matter consists of cells, cells are the structural and functional units of life, and all cells come from preexisting cells. Endosymbiosis has been proposed as the explanation for the origin of a defining cellular characteristic of all - Answer-Eukaryotes You are interested in studying a gene called CFTR because mutations in this gene cause cystic fibrosis. You have made a line of mice that l...

Describe the events of fertilisation that occur after the acrosome reaction. - Answer -Membrane of sperm and egg cell fuse together -cortical granules release contents into zona pellucida -Zona pellucida thickens -Haploid nuclei fuse Explain how phospholipids form a cell surface membrane - Answer -Hydrophilic parts associate with water -Hydrophobic parts repel water -a bilayer forms with hydrophobic parts pointing in towards the centre of the bilayer Describe the role of the ...

What does CFTR protein mean? - Answer Cystic Fibrosis Transmembrane Concordance Regulator (gated channel protein) What does ENaC stand for? - Answer Epithelial Sodium Ion Channel What happens if there is excess water in an unaffected person's airways? - Answer 1) Excess water detected by the epithelial cell membrane 2) Carrier proteins in the basal membrane actively pump sodium ions out of the cell into the tissue fluid 3) Sodium ions diffuse from the mucus, down the gradient by f...

RB is a 20 year old female recently approved for CF treatment with Trikafta® (elexacaftor/tezacaftor/ivacaftor). She is homozygous for the F508 del mutation in the CFTR gene and meets criteria for treatment with this medication. Her current medications include inhaled albuterol, normal saline, tobramycin, Advair® and Pulmozyme®. She is also taking buspirone, cetirizine, vitamin D3, insulin (regular and long acting), montelukast, omeprazole, and Creon®. What is an important counseling point t...

biomarkers Ans: -objective and quantifiable measurement or characteristic of a biological process -indicator of a biologic process -molecular pathology = gene or gene product associated with a disease process ideal biomarker Ans: -relevant and valid to a specific disease state -provides actionable or prognostic info -quantifiable in easily obtained tissue or fluid -economical to test in a reproducible fashion caveat to biomarkers Ans: -molecular pathology biomarkers can be the prot...

Cystic Fibrosis PathoMutation in gene CFTR on chromosome 7 Chloride channels are affected by the mutation in the gene - specifically, in the case of the lungs, chloride cannot be secreted across the epithelium into the lung tissue to moisten them Since the chloride is unable to be secreted the sodium is not secreted and neither in water, causing thick secretions in the lungs Tay Sachs PathoAccumulation of glycolipids in the brain neuron and retina due to failure of lysosome function . The Lys...