Ons oncc exam study guide - Study guides, Class notes & Summaries

STUDY GUIDE FOR ONS&ONCC FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY ADMINISTRATION EXAM What do alkylating chemotherapy drugs do? - CORRECT ANSWER-Chemotherapy drugs that are cell cycle nonspecific, so they exert their effects in all phases of the cell cycle. They directly damage DNA to prevent cancer cells from reproducing. They cause breaks in the DNA or cross-linking in a process called alkylation, which causes the drug to interfere with DNA replication. neoadjuvant therapy - ...

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Alkylating agents - Classification Break DNA helix strand, thereby interfering with DNA replication Altretamine (Hexalen) - Alkylating Agent PO Ovarian CA Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression