Gms 6552 - Study guides, Class notes & Summaries

Agonist Activation of GPCR - answer-Ligand binds Promotes conformational changes Increase in R Inverse Agonist Inhibition of GPCR - answer-Ligand binds Stabilizes inactive receptor conformations Antagonist Inhibition of GPCR - answer-Do not effect basal constitutive signaling Do not affect receptor conformation when they bind GPCR Full Agonist - answer-Produces full biological response GPCR Partial Agonist - answer-Can only produce partial biological response even at saturating c...

Most common drug target - answer-- receptors Channel-linked receptors - answer-- ion channels open when bound to ligand - hyperpolarization or depolarization - milliseconds - ex. nicotinic receptor, ACh receptor G-protein coupled receptors - answer-- use second messenger systems to induce cellular effects when bound - seconds - ex. muscarinic ACh receptor Kinase-linked receptors - answer-- cause protein phosphorylation inducing cellular effects when bound -minutes - ex. insulin r...

GMS 6552 Comprehensive Review Guide: Essential Questions and Answers 1. What is the relationship between oncogenes and proto-oncogenes? - ANSWER Proto-oncogenes become oncogenes during carcinogenesis 2. Which form(s) of oncogene activation involve(s) a mechanism that will NEVERdirectly change the DNA sequence in a cell? Choose all that apply. - ANSWER Hypomethylation 3. Does the presence of oncogenes make it harder or easier to develop selective anti-cancer agents with fewer side eff...