malaria life cycle
injected motile sporozoites; schizogony in liver; merozoites in erythrocytic cycle
sickle cell anemia produces ___
malarial resistance
duffy antigen
receptor for p. vivax merozoites
p. vivax
vivax malaria; young erythrocytes; RBC schizont rupture; relapse occurs; liver
hypnozoites
p. vivax ID
enlarged infected RBCs with Schuffner's dots
p. falciparum
falciparum malaria; high grade parasitemia; blackwater fever; non-relapsing; infected
RBCs stick to capillary linings
p. falciparum ID
RBCs w/ multiple ring stages; crescent gametocytes; Maurer's clefts; many infected
RBCs; no schizonts
babesiosis/Nantucket Island fever
deer tick; pinpoint lesions; cross-like morphology in RBCs
general properties of rickettsia
arthropod-borne diseases; obligate intracellular bacteria; humans as accidental hosts
rickettsial pathogenesis
multiply in endothelial cells; necrotizing vasculitis; increased microvascular permeability
r. rickettsii
rock mountain spotted fever; wild rodent reservoir; brown dog tick vector; centripetal
rash (extremities to trunk), fever, headache
r. akari
rickettsialpox; house mouse reservoir; house mouse mite vector; red papule & eschar
r. prowazekii
epidemic/louse-borne typhus; human reservoir; louse feces of human body louse
vector; centrifugal rash (trunk to extremities)
r. prowazekii, add'n diseases
Brill-Zinnser disease/recurrent typhus; sylvatic typhus - flying squirrel
r. typhi
endemic/murine typhus; rats & cats reservoir; feces of flea vector
rickettsioses treatment
doxycycline; chloramphenicol
general properties of anaplasmataceae
grow in leukocytes; morale; no transovarial tick transmission
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