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Maryville University Pharmacology 615 Exam 2 Study Guide Solutions
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Maryville University Pharmacology 615 Exam 2 Study Guide Solutions Oseltamivir (Tamiflu) - ANSWER-Neuramidase Inhibitor. Oral Antiviral for influenza A&B. Works by breaking the bond that attaches the viral particles to host cell. SE include headache, n/v, and CNS. Zanamivir (Relenza) - ANSWER-...

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  • November 18, 2024
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  • 2024/2025
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Maryville University Pharmacology
615 Exam 2 Study Guide Solutions

Oseltamivir (Tamiflu) - ANSWER✔✔-Neuramidase Inhibitor. Oral Antiviral for

influenza A&B. Works by breaking the bond that attaches the viral particles to host cell.

SE include headache, n/v, and CNS.


Zanamivir (Relenza) - ANSWER✔✔-Neuramidase Inhibitor. Inhaled Antiviral for

influenza A&B. Works by breaking the bond that attaches the viral particles to host cell.

Contraindicated for COPD. SE include headache, n/v, and CNS.


Amantadine (Symmetrel) - ANSWER✔✔-Inhaled Antiviral for Influenza A. Works by

binding to ion channels formed by the membrane protein of viral envelope. High pKA

so no absorption in stomach. CNS side effects like dizziness.


Rimantadine (Flumadine) - ANSWER✔✔-Inhaled Antiviral for Influenza A. Works by

binding to ion channels formed by the membrane protein of viral envelope. High pKA

so no absorption in stomach. CNS side effects like dizziness.


Acyclovir, Valacyclovir, Famciclovir - ANSWER✔✔-antivirals for HSV and VZV. Block

an enzyme that is essential in production of new viruses so virus cannot reproduce and

replicate. SE include headach and nausea.



Copyright ©SOPHIABENNETT 2025 ACADEMIC YEARALL RIGHTS RESERVED. Page 1/25

,Antivirals - ANSWER✔✔-Should be takens ASAP for effect (within 48-72 hrs of ONSET

of symptoms). For shingles or zoster, when you notice the rash, come in. For influenza,

early signs of flu, come in (sore throat, runny nose QUICK ONSET).


Amphotericin B - ANSWER✔✔-Polyene antifungal for LIFE THREATENING fungal

infections. Usually have been on chemo or poor immune systems. Disrupts the integrity

of fungal cell membrane.


Nystatin - ANSWER✔✔-Polyene antifungal works by disrupting the integrity of the

fungal cell membrane but only works for CANDIDA (unlike ammphotericin b). skin,

vaginal, oral/thrush.


itraconazole, fluconazole, posaconazole, voriconazole - ANSWER✔✔-triazole

antifungals. inhibit critical enzyme that causes a buildup of toxic substance and leads to

increased fungal membrane permeability (cell leaks out). CYP 450 system. lots of drug

interactions. SE include n/v.


Other -azoles (clotrimazole, ketoconazole, and miconazole) - ANSWER✔✔-imidazole

antifungals are like the traizole antifungals but are indicated specifically for

vulvovaginal, oropharyngeal, and tinea candidias infections. inhibit critical enzyme that

causes a buildup of toxic substance and leads to increased fungal membrane

permeability (cell leaks out). CYP 450 system. lots of drug interactions. SE include n/v.


allylamines (lamisil) - ANSWER✔✔-ORAL antifungal for onchomycosis. works like the

azole antifungals but highly active against dermatophytes so good for toenails and

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, fingernails that are infected. does not work well against candida. LIVER/GI issues

because take for 12 weeeks.


Pen-Lac - ANSWER✔✔-Topical antifungal indicated for onychomycosis.


griseofulvin - ANSWER✔✔-antifungal used for tinea infections. works well for tinea

capitis and works in children. inhibits mitosis of the fungal element. liquid form. if

taken with soda can absorb better.


tolnaftate (tinactin) - ANSWER✔✔-topical antifungal used for tinea infections. tinea

cruris or jock itch.


ethambutol - ANSWER✔✔-antitubercular drug. inhibits synthesis of mycolic acids

(important for mycobacterial wall). rapidly absorbed orally. NOT monotherapy. SE is

optic neuritis.


Isonazid (INH) - ANSWER✔✔-antitubercular drug. well absorbed, penetrates CNS.

potent. peripheral neuritis and hepatitis are side effects.


Pyrazinamide (PZA) - ANSWER✔✔-antitubercular drug. widely distributed

throughout all body tissues. bacteriostatic or bactericidal depending on dose. hepatic

toxicity side effect.


Rifabutin - ANSWER✔✔-Rifamycin. antitubercular drug. semisynthetic derivative of

the rifamycins. widely distributed. inhibits DNA-dependent RNA polymerase. (inhibits

protein synthesis).


Copyright ©SOPHIABENNETT 2025 ACADEMIC YEARALL RIGHTS RESERVED. Page 3/25

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