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AAB MT Hematology Exam Questions and Answers 100% Pass

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AAB MT Hematology Exam Questions and Answers 100% Pass What is hemoglobin composed of? - ANSWER-4 heme, 4 iron, 4 globins What disorder does a defect in heme synthesis lead to? - ANSWER-Porphyria Porphyria - ANSWER-Deficiency in the enzymes of the porphyrin pathway leads to insufficient produc...

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  • November 18, 2024
  • 28
  • 2024/2025
  • Exam (elaborations)
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SophiaBennett
AAB MT Hematology Exam Questions
and Answers 100% Pass

What is hemoglobin composed of? - ANSWER✔✔-4 heme, 4 iron, 4 globins


What disorder does a defect in heme synthesis lead to? - ANSWER✔✔-Porphyria


Porphyria - ANSWER✔✔-Deficiency in the enzymes of the porphyrin pathway leads to

insufficient production of heme. The principal problem in these deficiencies is the

accumulation of porphyrins, the heme precursors, which are toxic to tissue in high

concentrations.


What is methemoglobin? - ANSWER✔✔-Methemoglobin is a form of hemoglobin that

contains ferric [Fe3+] iron and has a decreased ability to bind oxygen. However, the

ferric iron has an increased affinity for bound oxygen. When methemoglobin

concentration is elevated in red blood cells, tissue hypoxia can occur.


What is the function of the enzyme methemoglobin-cytochrome C reductase in a red

blood cell? - ANSWER✔✔-To keep iron in the ferrous state


What product is formed when ferrous iron of hemoglobin is oxidized to the ferric state?

- ANSWER✔✔-Methemoglobin




Copyright ©SOPHIABENNETT 2025 ACADEMIC YEARALL RIGHTS RESERVED. Page 1/28

,What is carboxyhemoglobin? - ANSWER✔✔-A stable complex of carbon monoxide and

hemoglobin that forms in RBCs when carbon monoxide is inhaled or produced in

normal metabolism. Large quantities of it hinder delivery of O2 to the body. Tobacco

smoking (through carbon monoxide inhalation) raises the blood levels of COHb by a

factor of several times from its normal concentrations.


Which hemoglobin has a 200 times greater binding capacity for the hemoglobin

molecule than oxygen? - ANSWER✔✔-Carboxyhemoglobin


Which hemoglobin derivative causes irreversible changes in RBCs? - ANSWER✔✔-

Sulfhemoglobin -- makes blood incapable of carrying oxygen.


Which of the following hemoglobins is NOT normally present in a normal adult? -

ANSWER✔✔-Hb-S


Which embryonic hemoglobin is normally found in newborns? - ANSWER✔✔-Hb-F


What is the most abundant hemoglobin in a newborn? - ANSWER✔✔-Hb-F


What is the molecular structure of Hemoglobin S? - ANSWER✔✔-Valine replaces

glutamic acid in the 6th position of the beta chain


Which of the following hemoglobins is insoluble under lowered oxygen tension? -

ANSWER✔✔-Hb-S


What laboratory test is used to confirm the specific diagnosis of sickle cell anemia? -

ANSWER✔✔-Hemoglobin electrophoresis

Copyright ©SOPHIABENNETT 2025 ACADEMIC YEARALL RIGHTS RESERVED. Page 2/28

, In the solubility test for hemoglobin S, what is the reagent responsible for the reduction

of the hemoglobin molecule? - ANSWER✔✔-Sodium dithionite


In hemoglobin C, what replaces glutamic acid? - ANSWER✔✔-Lysine


Which red blood cell inclusion is characteristic of hemoglobin C disease? -

ANSWER✔✔-Rod-shaped crystals


What is hemoglobin F composed of? - ANSWER✔✔-2 alpha and 2 gamma chains


Which hemoglobin is resistant to alkali denaturation? - ANSWER✔✔-Hb-F


Which hemoglobins are differentiated by the Kleihauer-Betke technique? -

ANSWER✔✔-Hb-A1 from Hb-F


What is the order of migration of hemoglobins, from fastest to slowest, on cellulose

acetate at pH 8.4? - ANSWER✔✔-A1, F, S, C


Why is citrate agar used when abnormal hemoglobins are identified on cellulose acetate

at pH 8.6? - ANSWER✔✔-It separates hemoglobin S from hemoglobin D


The cyanmethemoglobin method measures all hemoglobin pigments EXCEPT which

one? - ANSWER✔✔-Sulfhemoglobin


What is the diluent used in the cyanmethemoglobin method for the determination of

hemoglobin? - ANSWER✔✔-Drabkin's solution


What is the normal plasma hemoglobin concentration? - ANSWER✔✔-2-3 mg/dL


Copyright ©SOPHIABENNETT 2025 ACADEMIC YEARALL RIGHTS RESERVED. Page 3/28

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