VIBS 422 EXAM 2
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1. What are plasticizers? Plasticizers are
additives that are
incorporated into
a material to in-
crease its flex-
ibility by weak-
ening the bonds
so the polymer
chains can move
more freely rela-
tive to one anoth-
er and polymer be-
comes less stiff.
2. The two most common plasticizers used today in PVC DEHP and DINP
are?
3. What is the chemical name of Phathalate? 1,2-benzene-dicar-
boxylic acid
4. What are the physical properties of DINP? superior anti heat,
anti-cold, and
anti-volatile prop-
erties
5. What are the physical properties of DIDP? low volatile prop-
erties, anti-heat
and anti-aging (for
the product) prop-
erties and low
insulation proper-
ties
6. River that was cleaned up and then recontaminated Duwamish River
with phthalates from storm water runoff?
7. Commencement Bay $103 million su-
perfund cleanup
, VIBS 422 EXAM 2
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-phthalate recont-
amination ongoing
8. How can we be exposed to phthalates? -inhalation: phtha-
lates erode off of
products & conta-
minate air
-ingestion: drink-
ing polluted water
due to plastics
-absorption: con-
tact with plastics
that are made of
DEHP
-medical proce-
dures: fluids and
drugs in plastic
bags, dialysis tub-
ing, heart bypass
surgery, and blood
transfusion prod-
ucts
-Work related:
jobs that create a
lot of contact with
DEHP
-Food: baked
goods, highest
levels found in milk
and cheese
-cosmetics, per-
fumes
9. List any 5 toxic effects of phthalates in females? -elevated serum
estradiol levels
-advanced onset
of puberty
-increased ovari-
an and uterine
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weights
-uterine malforma-
tions
-reduced fecundity
10. What are 4 major symptoms of Phthalates Syn- -leydig cell abnor-
drome? malities
-dysgenesis of
leydig cells
and seminiferous
tubules
-undescended
testes
-spermatogenic
failure and
infertility
11. Describe toxic effects of phthalates on male repro- -decrease in
ductive function anogenital dis-
tance (AGD)
-disrupts testicular
descent and de-
velopment of a
small and indis-
tinct scrotum
-DEHP disrupts
and decreas-
es spermatogen-
esis and lowers
the intra-testicu-
lar and plasma
testosterone lev-
els by directly act-
ing on leydig cells
12. What was the agent used in Vietnam? Agent Orange
13. What is the toxin in Agent Orange TCDD
14. TRUE
, VIBS 422 EXAM 2
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Phthalate metabolism: DEHP is oxidized to form
MEHP; MEHP is metabolized by different oxidation
reactions.
15. The symptoms of phthalate syndrome are leydig cell TRUE
abnormalities, undescended testes, and spermatoge-
nesis failure
16. Who discovered the first DDT in 1939? Paul Muller
17. Which is not a most common 2nd gen pesticide? BPA
18. What 4 crops account for 70% of insecticides in US? corn, cotton,
wheat, soy beans
19. (T/F) DDT is excreted in urine, feces, or breast milk. true
20. ID this EDC: phthalate
21. What EDC is a nonsteroidal estrogen given to women DES
to avoid pregnancy complications?
22. How is DES eliminated from the body? through the biliary
excretion in feces
23. (T/F) DES binds to androgen receptors. false
24. What is the half life of DES? primarily 3-5
hours; 2-3 days
due to entero-he-
patic recirculation
25. (T/F) Microplastics cannot cross the cell membrane. false
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