Neuropsychopharmacology Dr Tam Exam 1 Questions And Answers
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Course
NEUROPSYCHOPHARMACOLOGY
Institution
NEUROPSYCHOPHARMACOLOGY
Where are drugs synthesized? - ANS Outside the body (exogenous). Endogenous chemicals are biochemicals.
What are the three rules to follow biochemical ethics? - ANS 1.Reduce the pain/suffering of the patient.n2.Weigh the beneficial effects against the detrimental to decide. Incre...
Neuropsychopharmacology Dr Tam
Exam 1 Questions And Answers
Where are drugs synthesized? - ANS Outside the body (exogenous). Endogenous
chemicals are biochemicals.
What are the three rules to follow biochemical ethics? - ANS 1.Reduce the pain/suffering of
the patient.\n2.Weigh the beneficial effects against the detrimental to decide. Increase the
quality of life.
What is the definition of drug at the physiological\nlevel? - ANS Drugs are the induction
mechanisms for altering the\nphysiological functions of an animal (or plant).
What is the definition of drug at the neural level? - ANS Drugs are the chemical signals that
turn on (or off)\nspecific neural circuitry.
Regulation of receptors - ANS There are modified in number (long-term) and sensitivity
(short-rapid term via second messengers)
Receptor Subtype - ANS Drug receptor proteins that have different characteristics in
different target tissues.
What is an ionotropic receptor (ionic channel)? - ANS A receptor with a channel pore that
ions can flow through.
What is the predominant ion in the cell - ANS K+ is the predominant POSITIVE ion
Na/k pumps what - ANS 3 Na out for every 2 K in
what is the resting potential membrane - ANS -70mv
Main NT for Excitation - ANS Acetyl-choline and Glutamate
Main NT for Inhibition - ANS GABA, Glycine, Y-aminobutyric acid
Function of Na channel - ANS generation of action potential
Function of K channel - ANS return membrane to resting potential
, Function of Ca channel - ANS Stimulation of NT release from post synaptic neuron
Function of Cl - ANS
Drugs plotted on the same graph (dose x pain effectiveness) that reach at the same y-axis are
said to have.. - ANS Same efficacy
What happens to the dose response curve of an agonist when an antagonist is added. - ANS
The dose response curve moves to the right, but still able to achieve maximum effect, just more
of the agonist needed to be applied/added.
Any receptor that is not ionotropic is ___ - ANS Metabotrophic
An ion channel can either be ___ (+excitory) or ___ (-inhibitory) - ANS
depolarized\nhyperpolarized
Gs proteins ___ the production of chemicals while Gi ___ it - ANS stimulate\ninhibit
What is a drug action? - ANS molecular/biochemical action at the binding site
Self-medication can be beneficial or detrimental based on ___ - ANS pre-existing
conditions
What is an inverse agonist? - ANS renders real neurotransmitters useless in their presence
What is potency? - ANS more potent if small concentration=high effect
Potentiation - ANS Refers to the situation in which the combination of two drugs produces
effects that are great than the sum of their individuals effects
What is efficacy? - ANS how strong an effect is at the synapse level (measured in %)
What is competitive binding? - ANS binding can be displaced by another molecule
What does GABA stand for and what is its function? - ANS gamma amino butric
acid\ninhibitor of neurotransmitter
What are the receptors that GABA binds to? (subtypes) - ANS GABAa and GABAb
GABAa has how many binding sites and what ion passes through the channel? - ANS at
least 5, Cl-
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