Exam (elaborations)
CPHON CHEMOTHERAPY AND BIOTHERAPY EXAM
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CPHON CHEMOTHERAPY ANDBIOTHERAPY EXAM
Cell cycle Specific Agents - ANSWER Plant Alkaloids and Antimetabolites
Plant Alkaloids - ANSWER Etoposide (VP 16)
Tenoposide (VM 26)
Paclitaxel
Docetaxel
Topotecan
Irinotecan
Vincristine
Vinblastine
Vinorelbine
Antimetabolites - ANSWER Mercaptopurine
Thioguanine
5 Fluorouriacil
Gemcitabine
Fludarabine
Cladribine
Nelarabine
Clofarabine
,Cytarabine
Hydroxyurea
Methotrexate
Alkylating Agents - ANSWER Mechlorethamine
Cytoxan
Ifosfamide
Melphalan
Lomustine (CCNU)
Carmustine (BCNU)
Busulfan
Procarbazine
Thiotepa
Darcarbazine
Cisplatin
Carboplatin
Antitumor Antibiotics - ANSWER Dactinomycin
Bleomycin
Daunorubicin
Doxorubicin
Idarubicin
Mitoxantrone
Corticosteroids Commonly used as Chemotherapy - ANSWER
Dexamethasone
,Prednisone
Hydrocortisone
Methylprednisolone
Miscellaneous chemo - ANSWER Asparaginase
Retinoids
Imatinib (Gleevac)
Supportive Medications - ANSWER Allopurinol
Amifostine (Ethyol)
Dexrazoxane (Zinecard)
Leucovorin Calcium (Wellcovorin, citrovorum Factor, folinic acid)
Mesna (Mesnex)
Trimethoprim-sulfamethoxazole (TMP-SMZ, bactrim, Septrax, Co-trimoxizole)
Arsenic Trioxide - ANSWER Classification: Differentiating Agent
Route: IV
Common Side Effects: headache, dizziness, fatigue, fevers, rigors, reactions at
injection site, nausea, vomiting, diarrhea, elevated liver function tests,
myelosuppression
Occasional: Chest pain, pain at injection site, peripheral neuropathy, tremor
Rare: Hypersensitivity
, Special Considerations: Safety and efficacy have not been studied in children
younger than 5 years of age. Monitor QT prolongation. Heather provider
supplying subscription must be registered with company prior to ordering drug.
Asparaginase (Elspar) - ANSWER Classification: Miscellaneous, cell-cycle
nonspecific
Route: IM or IV
Common Side Effects: local allergic reaction, hyperammonemia, low
fibrinogen.
Occasional:rash, hyperglycemia, abnormal liver function tests, coagulation
abnormalities
Rare: hypersensitivity with anaphylaxis, nausea, vomiting, anorexia,
somnolence, lethargy, pancreatitis, convulsions, thrombosis, edema, CNS
ischemic attack, renal compromise
Special Considerations: IV administration returning to favor, PEG-asparaginase
has provided excellent asparagine depletion, use of E. Coli asparaginase or
erwinia asparaginase requires meticulous dosing schedules. Have emergency
equipment and drugs available. observe patient for 60 min after each dose.
coagulation abnormalities lace child at risk for thrombus formation and
bleeding.
Bleomycin Sulfate (Blenoxane) - ANSWER Classification: Antibiotic, cell-
cycle nonspecific
Route: IV, IM or Sub-Q
Common Side Effects: stomatitis, hyperpigmentation of fingernails
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