Clinical Pharmacology: Multiple Sclerosis Questions And
Answers With Verified Solutions (Graded A+) Latest
Update 2024/2025.
Progressive-Relapsing MS - ANSWER What type of MS does this describe: Steady decline since
onset with superimposed attacks.
Secondary Progressive MS - ANSWER What type of MS does this describe: Initial relapsing-
remitting MS that suddenly begins to have decline with our periods of remission.
Primary progressive MS - ANSWER What type of MS does this describe: Steady increase in
disability without attacks.
Relapsing-Remitting MS - ANSWER What type of MS does this describe: Unpredictable attacks,
which may or may not leave permanent defacers followed by periods of remission.
primary progressive MS - ANSWER All forms of MS are treated by drugs, except what type?
corticosteroids (IV methylprednisolone) - ANSWER What drug(s) are used to manage acute MS
attacks?
interferon beta and glatiramer - ANSWER What are the first line self injectables disease
modifying therapies for MS?
interferon beta - ANSWER What drug class has this MOA: Decrease IFN gamma release and
decrease class II MHC gene expression.
Avonex, rebiff, betaseron, and Copaxone - ANSWER What are the brand names for interferon
beta?
avonex, rebuff, and betaseron - ANSWER Which interferon beta(s) has/have an indication for
the relapsing forms of MS?
Plegridy - ANSWER Which interferon beta(s) has/have an indication for the relapsing remitting
forms of MS?
SubQ and IM - ANSWER How are the interferon betas administered (PO, IM, SUBQ, IV)?
Avonex (it is given IM) - ANSWER All interferon betas are given subQ, except which one?
Avonex - ANSWER Which interferon beta is injected weekly?
Rebif - ANSWER Which interferon beta is injected 3x/week?
Betaseron (Also called Extavia) - ANSWER Which interferon beta is injected ever other day?
Plegirdy - ANSWER Which interferon beta is injected every 14 days?
, Aconex (interferon-Beta 1a) and Rebif (Interferon-Beta 1a) - ANSWER What are the high
potency interferons beta?
Beraseron (Interferon-Beta 1b) and Plegridy (Peginterferon-beta 1a) - ANSWER What are the
low potency interferons beta?
relapsing remitting MS - ANSWER Interferon Beta had a 30-60% reduction in clinical relapse
rates in what type of MS?
False (they do not) - ANSWER True or False: Interferon beta increases quality of life in MS
patients.
True - ANSWER True or False: Interferon beta improves disease progression but not symptoms.
True - ANSWER True or False: There was a reduction in attack rate of high-rick clinically isolated
syndrome patients taking interferon beta.
patient with CIS (clinically isolated syndrome) with high risk of developing active MS and patients with
relapsing remitting MS and secondary progressive MS already experiencing relapses - ANSWER
Who is a candidate for therapy with interferon beta as first line therapy?
flu-like sx, injection site rxn, and depression - ANSWER What are the common adverse reactions
for interferon beta?
2-3 months (They will go away after taking the medication for this long) - ANSWER You have a
patient on interferon beta for MS. They are concerned because they have flu like sx for 24 hours after
administration. They ask you how long they can expect to have those SE. What can you tell them?
hepatotoxicity and myelosupression - ANSWER What are the rare and severe adverse reaction
for interferon beta?
rotate injection sites, warm medication to body temp, place ice on injection site after administration,
and administer topical corticosteroids - ANSWER What can you education a patient to do to
prevent or decrease injection site reactions/flu like symptoms if using interferon beta?
abortion - ANSWER What can interferon beta cause in women of childbearing age?
True - ANSWER True or False: Interferon beta is a potential abortafacient.
C - ANSWER Interferon Beta falls intro which pregnancy category?
CBC/platelets and LFT - ANSWER What labs should be monitored in patients on interferon beta?
baseline, 1 month, then q 3 months for 1 year, then q6 months - ANSWER How often should a
CBC be done in a patient who is starting on interferon beta?
baseline, 1 month, then q 3 months for 1 year, then q6 months - ANSWER How often should LFT
be done in a patient who is starting on interferon beta?
Glatiramer acetate (Copaxone) - ANSWER What drug can also be used first line for MS and has
improved efficacy over interferon beta?
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