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APHON PRINCIPLES OF BIOTHERAPY EXAM
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APHON PRINCIPLES OF BIOTHERAPYEXAM
Biotherapy: ANSWER mode of treatment: substances that mimic the body's
natural defensive and monitoring mechanisms. can direct anticancer activity,
enhance, modify, and repair the host's immunological ANSWER, among other
biological actions. usually hypersensitivity rx side effects
Immune surveillance: ANSWER tumour cells display aberrant tumour antigens
on their surface that the immune system can identify and eliminate.
Natural killer cells are ANSWER lymphocytes that identify and eliminate
cancerous cells.
ANSWER's cytotoxic T lymphocytes identify antigens linked to tumours and
eliminate cells.
Interferons are made with recombinant DNA and have several moas.
protein that inhibits viral replication to protect other cells from viral infections.
Glycoproteins have strong immunomodulatory, antiviral, and antiproliferative
properties.
Cytokines are ANSWER products produced by immune cells that boost immune
ANSWER and cell cytotoxic action.
hairy cell leukemia, melanoma, chronic myeloid leukemia, follicular lymphoma,
multiple myeloma, and cutaneous t-cell lymphoma. alpha-interferon-ANSWER
leukocyte-derived
ANSWER fibroblast-derived beta-interferon. tx MS
ANSWER t-lymphocyte-derived gamma-interferon. Chronic
Granulomatomatus Disease in Texas
, T-helper cells produce interleukin-2-ANSWER, which promotes the
development of cytotoxic T-cells, lymphokines, and cytokines as well as the
growth and maturation of t-cell subsets.
function as chemical messengers between WBCs (stimulating the immune
system)
Retinoids are ANSWER immunomodulators that promote cancer cell
differentiation and inhibit their growth.
ANSWER: all-trans retinoic acid (atra) tx: aml, aml m3 subtype, apl promote
promyelocytic blast maturation and coagulopathy resolution quickly in relation
to tx.
ANSWER retinoid tx neuroblastoma is treated with isotretinoin (accutane).
possess unknown moa antitumor activity. TERATOGENIC. Both male and
female patients need to sign up for iPledge (fetal exposure). can impact eyesight
and hearing as well.
ANSWER proteins, or antibodies, are made by b-lymphocytes. component of
the adaptive system's humoral immunity. consists of immunoglobulins (igG,
igA, igM, igE, and igD).
ANSWER microscopic-derived Human antimouse antibodies are produced by
MoAbs, increasing the likelihood of hypersensitivity. Rx ends in -momab.
ANSWER monoclonal antibodies are highly specific. targeted at a single
antigenic determinant on the cell surface that results in mild toxicity, antibody-
dependent cellular toxicity, direct cell death, and antigen/target cell elimination
-ximab-ANSWER moab combination of mouse and human antibodies
-zumab - ANSWER moab humanized, human antibody fused with a tiny portion
of mouse antibodies
ANSWER completely humanized moabs -umab
Chimeric moab: ANSWER recombinant DNA linked with a human constant
and a murine variable
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