Clinical Pharmacology Final Exam Questions And
Answers With 100% Correct Answers Latest Update
2024/2025.
3 physiological characteristics of asthma that cause symptoms - ANSWER Inflammation
Airway hyperresponsiveness
Airway obstruction
Goals of asthma tx in terms of reduction of SABA use - ANSWER Goal is to prevent SABA use
>2x/week
Intermittent asthma tx - ANSWER SABA PRN only
Persistent asthma tx - ANSWER Depends on severity -- at least ICS + SABA PRN
Step 1 Asthma therapy
-Who is this for?
-What is it? - ANSWER Intermittent asthma only
SABA PRN
Step 2 Asthma therapy
-Who is this for?
-What is preferred?
-Alternative therapies - ANSWER Persistent asthma
Low dose ICS
or...
Cromolyn
LTRA
,Nedocromil
Theophylline
Step 3 Asthma therapy
-Who is this for?
-What is preferred?
-Alternative therapies - ANSWER Persistent asthma
Low dose ICS + LABA or Medium dose ICS
or...
Low dose ICS + LTRA/Theo/Zileuton
Step 4 Asthma therapy
-Who is this for?
-What is preferred?
-Alternative therapies - ANSWER Persistent asthma
Medium dose ICS + LABA
or...
Med ICS + LTRA/Theo/Zileuton
Step 5 Asthma therapy
-Who is this for?
-What is preferred? - ANSWER Persistent asthma
,High dose ICS + LABA and...
Omalizumab if allergies
Step 6 Asthma therapy
-Who is this for?
-What is preferred? - ANSWER Persistent asthma
High dose ICS + LABA + oral corticosteroid and...
Omalizumab if allergic
When should an asthma patient be seen in primary care vs. by an asthma specialist? - ANSWER
Primary care if Step 1-3
Consult asthma specialist at Step 3
Asthma specialist should take over care if Step 4-6
What is considered "inadequate control" of asthma symptoms? - ANSWER Need for SABA use
>2 days/week (as symptom control, not preventive for exercise-induced)
How should you be using SABAs? - ANSWER Everyone with asthma gets one -- can be used 3x at
20-minute intervals
Short-Acting Beta2 Receptor Agonists
Used for... (2)
Name the drugs (3)
Routes
Onset and duration - ANSWER Used for acute bronchospasm (rescue inhaler) and prevention of
exercise-induced asthma
Albuterol (ProAir, Proventil)
, Levalbuterol (Xopenex)
Pirbuterol (Maxair)
A and L can be nebs
All come as inhalers
A and L: 10 minute onset, 3-4 hour duration
P: 30 minute onset, 5 hour duration
Long-Acting Beta2 Receptor Agonists
Usage (when/how)
Name the drugs (2)
Warning
Routes
Onset and duration - ANSWER Used in combination with inhaled corticosteroids for LONG-TERM
control of asthma (Step 3+)
Salmetrol (Serevent) - powder inhaler
Formoterol (Foradil) - capsule inhaler or neb
BBW: used without ICS increases risk of asthma-related death
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