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BMS 300 EXAM 3 QUESTIONS AND ANSWERS
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BMS 300 EXAM 3 QUESTIONS ANDANSWERS
What are the sex determinants in females XX? - ANSWER Rspo1 and Wnt4/
Beta-catenin
What are the sex determinants in males XY? - ANSWER Sry and Sox9
PGC differentiation in XX - ANSWER Mesonephros --> Retinoic Acid -->
Gonad --> no CYP26B1 --> Meiotic entry PGCs
Differentiation of Primordial Germ Cell (PGC), XY - ANSWER Mesonephros -
-> Retinoic Acid --> Gonad -->CYP26B1 --> No Meiotic entry PGCs
True or False? Primary/Gonad sex differentiation does NOT depend on PGC
differentiation. - ANSWER True
Developed by Wolffian Duct - ANSWER Epididymis (Testis), Vas Deferenes,
Seminal Vesicle
Developed by Mullerian Duct - ANSWER Ovary (Oviduct/ "Fallopian Tube"),
Uterus, Upper 1/3 of Vagina
Removing the gonads of rabbits shows us that: -
ANSWER The ovary does nothing in development
, Removing the gonads of rabbits, and adding testosterone shows us that: -
ANSWER Male development is greatly dependant upon testosterone.
Removal of the gonads of rabbits, taking testis fragments and putting them back
in, shows us that: - ANSWER Anti-Mullerian Hormone is present and secreted
by Sertoli cells and gets ride of the Mullerian Duct.
External genitalia development can be bi-potential. Bi-potential means that: -
ANSWER Either one of the two outcomes is possible, it just depends on the
factors present, and what is released, and what is blocked.
Androgen Insensitivity Syndrome (testicular feminization syndrome) -
ANSWER Mutation in androgen receptor that causes:
Chromosomal Sex: XX
Gonadal Sex: Undescended testes
Phenotypic Sex: female
Androgen - ANSWER Sex Steroid Hormone. Testosterone (ovaries and
testes). Dihydrotestosterone.
Estrogen - ANSWER Sex Steroid Hormone. Estradiol (ovaries and testes).
Progesterone - ANSWER Sex Steroid Hormone. Precursor.
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