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Pain Pathophysiology and Opioid Analgesics-Hasan Questions With Complete Solutions
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Pain Pathophysiology and Opioid Analgesics-Hasan Questions With Complete Solutions
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Pain Pathophysiology and Opioid Analgesics-HasanQuestions With Complete Solutions
A-alpha and A-beta nerve fibers in the periphery are responsible
for what 2 functions? Correct Answer touch and pressure
sensing
A-delta nerve fibers in the periphery are responsible for what 2
functions? Correct Answer pain and temperature
A-delta nerve fibers in the periphery primarily release what
neurotransmitter? Correct Answer glutamate
Activation of opiate receptors __________________
presynaptic neurons and ________________ pain transmission
to the brain.
a. hyperpolarize; inhibit
b. depolarize; inhibit
c. depolarize; enhance
d. depolarize; inhibit Correct Answer a
All of the following are receptors for glutamate EXCEPT:
a. AMPA-R
b. NMDA-R
c. mGlu-R
d. NK-1-R Correct Answer d
All of the following are true about substance P EXCEPT:
a. released by C-nerve fibers
b. causes tissue inflammation
c. mediates slow pain signals
,d. causes neurogenic inflammation
e. released by prodromic impulses Correct Answer e
All of the following can CAUSE pain EXCEPT:
a. glutamate
b. GABA
c. glycine
d. Substance P
e. CGRP Correct Answer bc
Buprenorphine has a ________ affinity and acts as a _________
at mu receptor.
a. low; full agonist
b. low; partial agonist
c. high; full agonist
d. high; partial agonist Correct Answer d
C type nerve fibers in the periphery are responsible for what 2
functions? Correct Answer slow pain and temperature
C type nerve fibers in the periphery primarily release what
neuropeptide? Correct Answer substance P
Factors that contribute to opioid abuse include all of the
following except:
a. positive reinforcement: obtaining euphoria
b. negative reinforcement: avoiding withdrawal symptoms
c. lack of fear of overdose
d. tolerance and physical dependence Correct Answer c
Fentanyl overdose is difficult to treat because?
, a. fentanyl is highly potent
b. fentanyl is highly lipophilic
c. fentanyl has a long duration of action
d. fentanyl irreversibly binds mu receptors Correct Answer ab
Fill in the blank:
Glutamate is a neurotransmitter involved in __________ pain
signal transmission and the effects of glutamate are sustained
and maintained by ___________________. Correct Answer
fast; substance P
GABA, glycine, 5-HT, NE, and endogenous opioids have what
effect on the body? Correct Answer pain reducing
Glutamate, substance P, and CGRP have what effect on the
body? Correct Answer pain inducing
Inhibitor interneuron signals that attempt to control pain in the
body primarily do this through the release of what
neurotransmitters (2)? Correct Answer GABA and glycine
Neurogenic inflammation is induced by what two endogenous
substances? Correct Answer substance P and CGRP
Pain mediators such as bradykinin and substance P induce pain
as they are coupled to _______, leading to depolarization of
nerve fibers.
a. Gq11
b. Gs
c. Gi
d. Cl- ion channel Correct Answer a
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