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NAU BIO 344 Posner Final Exam Questions and Answers
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NAU BIO 344 Posner Final Exam Questions and Answers
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NAU BIO 344 Posner Final Exam Questions andAnswers
What is true concering the monmeric GTPase Ran that we discussed earlier in the course?
Correct Ans-Ran GAP promotes the conversion of Ran-GTP to Ran-GDP
A synaptic vesicle is a small secretory vesicles that is used to store neurotransmitters for rapid
signaling across a chemical synapse. Where do most synaptic vesicles come from? Correct
Ans-recycling of components from the presynaptic plasma membrane
If something is a constitutive process, this means that: Correct Ans-there is no signal, it is
just constantly occurring
If something is a constitutive process, this means that: Correct Ans-there is no signal, it is
just constantly occurring
The receptor for Mannose 6 Phosphate (M6P) is Correct Ans-a transmembrane protein
found in the trans golgi that bind lysosomal hydrolases
The adaptin that binds LDL receptors to Clathrin is AP2. An individual who has a deletion in the
gene that codes for AP2 (that is to say, they do not make AP2) would: Correct Ans-have
abnormally high levels of cholesterol in their blood
Pinocytosis: Correct Ans-is a constitutive process that does not require a signal
,Cancer cells metabolize most of their glucose to: Correct Ans-lactate
Activation of the RTK-Ras-PI3K pathway will promote: Correct Ans-cell growth, survival and
proliferation
A difference between a malignant tumor and a benign tumor is that malignant tumors:
Correct Ans-have acquired characteristics of invasiveness.
One way cancer cells differ from normal cells is in their metabolism of glucose. What effect is
this phenomena known as? Correct Ans-Warburg Effect
Which of the following statements is FALSE regarding Ras mutations in cancer patients?
-Oncogenic mutations usually result in higher levels of GDP-bound Ras
-Mutations often occur at codons 12, 13, or 61
-Cells often have compromised activity of GTPase-activating proteins (GAPs)
-Ras mutations lead to activation of PI3 Kinase
-Mutations in Ras are often found in tumor cells in many types of cancer Correct Ans-
Oncogenic mutations usually result in higher levels of GDP-bound Ras
Genetic instability would be caused by: Correct Ans-defects in the ability to repair DNA
damage
, Proto-oncogenes: Correct Ans-are genes that can undergo a gain of function mutation
Which of the following is NOT true of somatic mutations? Correct Ans-They can be passed
on from parent to child
p53 induces the transcription of p21. p21 is a: Correct Ans-protein that inhibits cyclin
dependent kinases (CDKâ s)
Which of the following statements about AKT is FALSE?
-AKT is tethered to the plasma membrane by PI(3,4,5)P3
-AKT is activated downstream of PI3K.
-AKT activation may result in activation of mTOR.
-AKT activation may inhibit apoptosis through downstream inactivation of Bad. Correct Ans-
None of the choices concerning AKT are false
RASA1 is a RasGAP. Which of the following would you expect to be true concerning RASA1?
-it is a tumor suppressor
amplification of RASA1 is oncogenic
-it is a proto-oncogene
-it functions to increase Erk activity
-it is an oncogene Correct Ans-it is a tumor suppressor
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