Formerly known as neuroleptics, used to treat the symptoms of psychosis - delusions
and hallucinations
Mechanism of Action of Antipsychotic drugs
Block receptors of dopamine
Which dopamine receptors are associated with mental illness?
D2, D3, D4
Clozapine (Clozaril)
Atypical Antipsychotic drug that is relatively weak blocker of D2 that can lower
incidence of EPS?
AKA "Dopamine System Stabilizer"
3rd Gen Antipsychotics
Sesame Oil
Depot Injection
A time-release form of intramuscular injection for maintenance therapy.
7 to 28 days (1 week - 4 weeks)
Duration of Decanoate Fluphenazine (Prolixin)
4 weeks
, Duration of Decanoate Haloperidol (Haldol)
Zyprexa Relprevv
Medication that has potential to cause postinjection delirium/sedation syndrome.
Atypical Antipsyhotics
Puts the older clients most at risk for death
Extrapyramidal Symptoms
Major side effects of Antipsychotic Drugs
Blockade of D2 receptors in Midbrain Region of Brain Stem
Responsible for the development of EPS
Ziprasidone (Geodon) - 2nd Gen / Atypical
Contraindicated in clients w/ a history of QT prolongation, recent MI or HF.
Anticholinergic drugs - IM Benztropine Mesylate (Cogentin) or IM / IV Dephenhydramine
(Bendryl)
Immediate treatment for Acute Dystonic Reactions
Propanolol (Inedral)
Type of Beta Blocker included in treatment of EPS
Pseudoparkinsonism
Referred as generic label of Extrapyramidal Symptoms
Prolactin Levels
Antipsychotic drugs increase this in blood serum that results to:
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