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NURS 5463 Module 5: Sepsis Questions and Answers 100% Verified
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Metabolic changes - ️️Hyperglycemia Cellular glucose overload and severe oxidative stress leads to endothelial dysfunction and decreased neutrophil function Can also damage mitochondria due to oxidative stress Improving hypoperfusion - ️️Fluid administration Vasopressors Inotropes Ol...

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  • November 9, 2024
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  • 2024/2025
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  • NURS 5463 Module 5: Sepsis
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NURS 5463 Module 5: Sepsis
Metabolic changes - ✔️✔️Hyperglycemia
Cellular glucose overload and severe oxidative stress leads to endothelial dysfunction
and decreased neutrophil function
Can also damage mitochondria due to oxidative stress

Improving hypoperfusion - ✔️✔️Fluid administration
Vasopressors
Inotropes


Old sepsis definition - ✔️✔️SIRS
Sepsis
Severe sepsis
Septic shock

New sepsis definition - ✔️✔️Sepsis
Septic shock

Sepsis - ✔️✔️Life-threatening organ dysfunction caused by a dysregulated host
response to infection

qSOFA - ✔️✔️Mental status
Systolic blood pressure < 100
Respiratory rate > 22

Immune dysregulation - ✔️✔️Overproduction of cells which can amplify the
inflammatory response because of the attraction of pro-inflammatory cells


Mitochondrial dysfunction - ✔️✔️Results in loss of vascular tone, vasodilation, fluid
redistribution
Microvascular shunting leading to hypoxia

Epithelial dysfunction - ✔️✔️Allows movement of fluids between barriers which results
in increased capillary leakage

Coagulation activation - ✔️✔️Pro-inflammatory and further perpetuates immune
response

Lactic acid - ✔️✔️Indicator of inadequate clearance
Body's method for producing fuel for cells during stress
During sepsis, represents global tissue hypoxia and increased organ dysfunction

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