What antimicrobial drugs cause kidney damage? - ️️Bacitracin
Vancomycin
What drugs can prevent peptide cross bridges from being made? - ️️Vancomycin
Cycloserine
Which drugs bind to transpeptidases? - ️️Penicillin
Cephalosporins
What do transpeptidases do? - ️️They connect the ...
What drugs are effective against mycobacterium? - ✔️✔️Isoniazid
Ethambutol
T/F: Drugs that target cell wall synthesis only affect growing cells - ✔️✔️True
What was the first anti microbial agent ever used? - ✔️✔️Sulfa drugs in 1935
What the first antimicrobial agent ever discovered - ✔️✔️Penicillin 1929
Who discovered the first ever antibiotic? - ✔️✔️Alexander Fleming
What was the most stable penicillin isolate? - ✔️✔️Penicillin G
What were the two major drawbacks of penicillin G? - ✔️✔️It was unstable in an acidic
environment and couldn't be taken orally
It was only effective against gram positive organisms
, What chemical structure is found in all penicillins? - ✔️✔️A beta lactam ring
How many different types of beta lactamases are known? - ✔️✔️30
Which two drugs work well against pseudomonas aueriginosa? - ✔️✔️Ticarcillin
Piperacillin
What drug has replaced methicillin in the USA? - ✔️✔️Oxacillin
What method of action to all beta lactam containing drugs work by? - ✔️✔️Inhibition of
cell wall synthesis
What drugs are classified by generation? - ✔️✔️Cephalosporins
What advantage do later generation cephalosporins have over 1st generation
cephalosporins? - ✔️✔️Greater activity against:
G neg rods
Beta lactamase producers
Which drugs chemical structure has only one ring? - ✔️✔️Monobactams
What is an example of a monobactam? - ✔️✔️Aztreonam
What drug is considered to have the broadest antimicrobial spectrum? -
✔️✔️Imipenem
What broader category of drugs does imipenem fall under? - ✔️✔️Carbapenems
What is the most common beta lactamase blocker? - ✔️✔️Clavulanic acid
Which two drugs do we usually use claculanic acid with? - ✔️✔️Amoxicillin
Ticarcillin
What is the difference between the cell membrane of eukaryotes and prokaryotes? -
✔️✔️Eukaryote cell membranes contain sterols like cholesterol and egrosterol
In what ways can we attack a cell membrane using drugs? - ✔️✔️1) attach to
phospholipids
2) combine with sterols
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