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MMSC490 Exam 2 Questions And Answers
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MMSC490 Exam 2 Questions And Answers MMSC490 Exam 2 Questions And Answers MMSC490 Exam 2 Questions And Answers
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MMSC490 Exam 2Which eukaryotic DNA polymerase replicates the lagging strand in the 3ʹ to 5ʹ direction?
a. α
b. γ
c. δ
d. None of the above; the lagging strand is replicated in the 5ʹ to 3ʹ direction. - CORRECT ANS d. None of
the above; the lagging strand is replicated in the 5ʹ to 3ʹ direction.
DNA polymerases can synthesize DNA:
a. de novo, by catalyzing the polymerization of free dNTPs.
b. by adding dNTPs to complementary dNTPs on a single-stranded DNA.
c. by adding dNTPs to a hydroxyl group on the end of a growing polynucleotide chain hydrogen-bonded
to a strand of RNA.
d. by adding dNTPs to a hydroxyl group on the end of a growing polynucleotide chain hydrogen-bonded
to a strand of DNA. - CORRECT ANS d. by adding dNTPs to a hydroxyl group on the end of a growing
polynucleotide chain hydrogen-bonded to a strand of DNA.
In addition to synthesizing DNA, DNA polymerase I has a second catalytic activity: it can
a. synthesize short RNA sequences.
b. synthesize short polypeptide sequences.
c. remove RNA primers.
d. ligate short segments of DNA together. - CORRECT ANS c. remove RNA primers.
Which eukaryotic DNA polymerase replicates the leading strand in the 5ʹ to 3ʹ direction?
a. α
b. ε
,c. δ
d. γ - CORRECT ANS b. ε
Free rotation of one cut DNA strand around one uncut strand is the primary function of:
a. topoisomerase I.
b. topoisomerase II.
c. DNA helicase.
d. DNA polymerase. - CORRECT ANS a. topoisomerase I.
The function of topoisomerase II is to:
a. resolve DNA tangles.
b. allow DNA to swivel and unwind.
c. allow daughter chr
d. all of the above - CORRECT ANS d. all of the above
Autonomously replicating sequences are:
a. yeast plasmids.
b. yeast telomeres.
c. bacterial plasmids.
d. yeast origins of replication. - CORRECT ANS d. yeast origins of replication.
Telomeres are the:
a. midpoints of chromosomes.
b. microtubule attachment points on chromosomes. c. end-sequences of chromosomes.
d. enzyme complexes that complete DNA replication. - CORRECT ANS c. end-sequences of
chromosomes.
,Point mutations in DNA result from:
a. incorporation of incorrect bases during replication.
b. changes as a result of chemical exposure.
c. changes as a result of radiation exposure.
d. All of the above - CORRECT ANS d. All of the above
The most common cause of skin cancer is damage to DNA by:
a. infrared light.
b. ultraviolet light.
c. γ radiation.
d. β particle radiation. - CORRECT ANS b. ultraviolet light.
Pyrimidine dimers:
a. block DNA replication and transcription.
b. can be repaired by photoreactivation.
c. can be repaired by nucleotide-excision repair.
d. All of the above - CORRECT ANS d. All of the above
Cultured cells from xeroderma pigmentosum patients were unable to carry out:
a. base-excision repair.
b. nucleotide-excision repair.
c. synthesis of melanin.
d. DNA synthesis. - CORRECT ANS b. nucleotide-excision repair.
, E. coli DNA polymerase V:
a. is induced in response to high temperatures.
b. recognizes thymidine dimers and inserts nucleotides on the opposite strand.
c. has a low frequency of errors.
d. is activated during transcription. - CORRECT ANS b. recognizes thymidine dimers and inserts
nucleotides on the opposite strand.
Site-specific recombination:
a. occurs in randomly occurring DNA sequences.
b. is mediated by proteins that recognize specific DNA target sequences.
c. leads to programmed cell death.
d. is also referred to as homologous recombination. - CORRECT ANS b. is mediated by proteins that
recognize specific DNA target sequences.
Site-specific recombination occurs commonly during:
a. mitosis of somatic cells.
b. meiosis of germ cells.
c. development of immune-system cells.
d. prokaryotic cell division. - CORRECT ANS c. development of immune-system cells.
The DNA sequence to which an RNA polymerase binds to initiate transcription of a gene is called a(n):
a. enhancer.
b. promoter.
c. polymerase-binding element.
d. origin of transcription. - CORRECT ANS b. promoter.
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