GMS6504 Exam 1 Questions And Answers Rated A+
Which of the following would best be described as a system independent parameter determining pharmacological response?
Receptor affinity for the ligand
When taking a natural agonist and converting it to an antagonist using synthetic chemistry, what a...
GMS6504 Exam 1 Questions And Answers Rated A+
Which of the following would best be described as a system independent parameter determining
pharmacological response?
Receptor affinity for the ligand
When taking a natural agonist and converting it to an antagonist using synthetic chemistry, what are
the desired effects on affinity and efficacy?
Affinity increases, efficacy decreases
In the Langmuir equation, which variable represents the proportion of receptors that are bound by
ligand?
Kd
If a ligand has an intrinsic activity, α, of 0.54, this ligand is best considered a _____
partial agonist
If you do a cell culture experiment where you exogenously express a receptor in cells, which variable
in the equation R = f(α •r • Rt) are you most directly controlling?
Rt
With an efficacy-driven agonist, reducing the number of receptors present will shift the response
curve _____.
right
Applying the two-state theory of receptors to an ion channel, which state(s) would be active?
Ropen, ARopen
In a two-state system that allows for spontaneously active receptors, increasing the expression levels
of receptor in the absence of agonist will have what effect on measured response?
Increase
In the extended ternary complex model of receptors, which state(s) will result in subsequent
downstream signaling? Select all that apply
ARaG, RaG
Addition of an inverse agonist to a system containing a receptor that does not spontaneously activate
will have what effect on the measured response in the absence of any other ligand?
Have no effect
You use an agonist to treat two systems that are identical other than the number of receptors present.
System A required 1 mM of the ligand to reach 100% response while system B required 100 mM.
Which system has the larger receptor reserve?
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