PCP Questions and Answers
What are chlorophenicols and Nitrophenicols
Chlorinated hydrocarbon insecticide and fungicide
What does PCP stand for
Pentachlorophenicol
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PCP Questions and Answers
What are chlorophenicols and Nitrophenicols - answer Chlorinated hydrocarbon
insecticide and fungicide
What does PCP stand for - answer Pentachlorophenicol
What is PCP used for - answer Used to be used by certified applicators as a wood
preservative to protect lumber; may still be used at times
What is an environmental concern with PCP - answer Volatile and can give off
vapors in toxic concentrations especially at high ambient temperatures
How do animals develop PCP toxicosis - answer Licking wood that has been treated
Inhalation of toxic amounts from treated walls in sheds and barns (even if applied
months to years earlier)
Ingestion
Is PCP toxicity acute, subacute or chronic - answer Acute toxicity (within minutes)
Can also be chronic
What is the relative toxicity of PCP - answer Moderately toxic
What are factors that increase PCP toxicity - answer High ambient temperatures
Previous exposure
Poor condition, newborn
Hyperthyroidism
What are factors that decrease PCP toxicity - answer Cold temperatures
Anti-thyroid drugs
Body fat
What is the ADME of PCP toxicty - answer Absorption -readily absorbed from GIT,
Inhalation and intact skin
Distribution -wide with accumulation in fat
Metabolism -conjugation to glucuronic acid
Excreted -in urine as glucuronic acid
What is the MOA of PCP toxicity - answer Uncouples oxidative phosphorylation
resulting in decreased ATP production -end result is neurotoxicity, hyperthermia and
metabolic acidosis
What are the clinical signs of PCP toxicity - answer Acute toxicity may be so rapid no
signs are seen
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