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13: B Cell Development Exam Study Guide Solutions Antibody reaction to bacterial toxins - ANSWER-Cell with receptor for toxins interacts with bacterial toxins, resulting in specific antibody localization to site of infection Antibody reaction to bacteria in extracellular space - ANSWER-Macropha...

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  • November 3, 2024
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KaylinHoffman
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13: B Cell Development Exam Study Guide

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Antibody reaction to bacterial toxins - ANSWER✔✔-Cell with receptor for toxins interacts with bacterial

toxins, resulting in specific antibody localization to site of infection


Antibody reaction to bacteria in extracellular space - ANSWER✔✔-Macrophages interact with bacteria in

extracellular space and specific antibodies are localized to the site of infection. Complement activation

may also be included.


B Cell Development: Phase I - ANSWER✔✔-Repertoire assembly: Generation of diverse and clonally

expressed B-cell receptors in the bone marrow via VDJ recombination


B cell Development: Phase II - ANSWER✔✔-Negative selection: Alteration, elimination, or inactivation of

B-cell receptors that bind to components of the human body


B cell Development: Phase III - ANSWER✔✔-Positive selection: Promotion of a fraction of immature B

cells to become mature B cells in the secondary lymphoid tissues


B cell Development: Phase IV - ANSWER✔✔-Searching for infection: Recirculation of mature B cels

between lymph, blood, and secondary lymphoid tissues


B cell Development: Phase V - ANSWER✔✔-Finding infection: Activation and clonal expansion of B cells

by pathogen-derived antigens in secondary lymphoid tissue




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, Copyright © KAYLIN 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED FIRST PUBLISH NOVEMBER, 2024


B cell Development: Phase VI - ANSWER✔✔-Attacking infection: Differentiation to antibody-secreting

plasma cells and memory B cells in secondary lymphoid tissue


Cell types in B cell development: bone marrow - ANSWER✔✔-1. Stem cell: u germline


2. Early pro-B cell: u germline, κ/λ germline


3. Late pro-B cell: uDJ, κ/λ germline


4. Large pre-B cell: uVDJ, κ/λ germline


5. Small pre-B cell: uVDJ, κ/λ germline


6. Immature B cell: uVDJ, κ/λ VDJ


What is special about pro-B cells? - ANSWER✔✔-- No immunoglobulin


- Undergoes heavy chain rearrangement


What is special about pre-B cells? - ANSWER✔✔-- Only u chain


- Expresses a pre-B cell receptor: a heavy chain and a surrogate light chain


- Undergoes light chain rearrangement


What is the purpose of the surrogate light chain that binds to pre-B cells? - ANSWER✔✔-The surrogate

acts as a light chain mimic for heavy chain to bind to in order to make sure heavy chain is functional


Early pro-B cell rearrangements - ANSWER✔✔-- H-chain gene rearrangement


- D-J rearrangements on both chromosomes


Late pro-B cell rearrangements - ANSWER✔✔-- H-chain gene rearrangement


- VDJ rearrangement on first chromosome

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