Pharmacology 5334 Final Exam Study Guide
Questions and Answers 2024-2025
PCN drug-drug interactions - Correct Ans--aminoglycosides
-bacteriostatic antibiotics
-probenecid
Treatment for ONYCHOMYCOSIS - Correct Ans-Terbinafine (Lamisil) 1 tab daily x 3-6
months po
Best treatment for chlamydia - Correct Ans-Aziythromycin 1gm 1x dose
or
Doxycycline 100 mg po twice a day for 7 days
Patient with vaginal candidiasis, what is the treatment? - Correct Ans-Fluconazole
150mg po once
Treatment for uncomplicated cervical gonorrhea - Correct Ans-Ceftriaxone, 250 mg IM
once, plus azithromycin, 1 g PO once
Patient with tinea capitis, what is the TX? - Correct Ans-Very difficult to treat topically
Griseofulium po 6-8 weeks
or
Terbinafine (Lamisil) po 2-4 weeks
Narrow Spectrum PCN - Correct Ans-PCN G (procaine), PCN G (benzathine), PCN V
Bugs they fight: GRAM(+) cocci- 1st drug of choice against Strep (pneumonia,
pharyngitis, endocarditis) , Clostridium (tetanus, anthrax, gas gangrene)Neisseria,
spirochete (syphilis)
Lauren comes into the clinic and is diagnosed with Trichomoniasis. The NP can
prescribe: - Correct Ans-Metronidazole, 2 g PO once or
Tinidazole, 2 g PO once
Penicillinase-resistant PCN - Correct Ans-Oxacillin, Nafacillin, Dicloxacillin
Bugs they fight: Staph
Broad spectrum PCN - Correct Ans-Ampicillin- ampiciliin/sulbactam (Unasyn)
Amoxicillin- amoxicillin/ER (Moxatog), Amoxicillin/Clavulanate(Augmentin)
Bugs they fight: Good against GRAM (-)H. influenza, e-coli, proteus mirabilis,
enterococci, salmonella and shigella
Extended Spectrum PCNs - Correct Ans-Piperacillin/tazobactam (Zosyn)
Bugs they fight: same as broad spectrum + pseudomonas, klebsiella, bacterial fragilis
, Beta-lactamase inhibitors - Correct Ans-clavulanic acid, sulbactam, tazobactam
**Can not be given on their own, only in combo with PCN's i.e.> Augmentin, Unasyn,
Zoysn
Cephalosporin Generation 1 - Correct Ans--cephalexin
-cephazolin
-cephadoxil
**Cephlasporinase will destroy**
Not the drug of choice for active infections- good for prophylaxis prior to sx
Cephlasporin (2nd generation) - Correct Ans-Cefuroxime-most common
Bugs they fight: h.influenza (pneumonia), otitis sinusitis, res. tract infection
Cephlasporin (3rd generation) - Correct Ans-Cefotaxime, Cefdinir, Cefixime,
Cefodoxime, Ceftaazidime, Ceftibuten, Ceftriaxone
**Can penetrate CSF fluid**
Bugs they fight: Great against GRAM (-) bacteria causing meningitis, h.influenza,
klebsiella, proteus, salmonella
Cephlasporin (4th generation) - Correct Ans-Cefepime-hospital associated pneumonia's
& Ceftolozone/tozobactam (Zerbaxa)- complicated UTI's and intraabdominal infections
Cephlasporin (5th generation) - Correct Ans-Ceftaroline (Teflaro)-MRSA
Cephalosporin and PCN - Correct Ans-Cross allergy w/PCN
Carbapenems - Correct Ans-Only 4: Imipenem, Meropenem, Ertrapenem, Doripenem
EXTREMELY broad spectrum, **only given IV**
not active against MRSA
Iminpenem-cilastatin - Correct Ans-Most effective antibiotic against anaerobic bacteria
Highly effective against Gram (+/) cocci & bacilli
Meropenem - Correct Ans-Bacterial meningitis-3m and up
Intraabdominal infections across ages
complicated skin infections
Ertrapenem (Invanz) - Correct Ans-Pelvic infections
Community acquired pneumonia
Complicated UTIs
Abdomen/skin infections
Vancomycin treats - Correct Ans-gram positive- staph aureus/epiderm, c.diff
Vancomycin AE - Correct Ans-ototoxicity, nephrotoxicity, red man syndrome
