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BICH 411 Final Exam Review Questions and Answers

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BICH 411 Final Exam Review Questions and Answers 3. which of the following cannot travel through the liver mitochondrial mem- brane?: NH4+ 4. what is the function of N-acetylglutamate?: N-acetylglutamate activates car- bamoyl phosphate synthetase I (CPS I) 5. early in its life, a tadpole lives i...

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  • October 25, 2024
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BICH 411 Final Exam Review Questions and Answers




1. an infant won't eat, has persistent vomiting, is lethargic and is failing to thrive. these are the

classic symptoms of hyperammonemia. a blood sample confirms this hypothesis and also reveals

that the circulating plasma concen- tration of urea extremely low. a biopsy of the liver showed

abnormally high levels or arginosuccinate with no detectable arginine. the infant most likely has

a defect in : arginosuccinate lyase

2. what is the carbon source is urea?: HCO3-

3. which of the following cannot travel through the liver mitochondrial mem- brane?: NH4+

4. what is the function of N-acetylglutamate?: N-acetylglutamate activates car- bamoyl phosphate

synthetase I (CPS I)

5. early in its life, a tadpole lives in an aqueous environment and excretes much of its excess

nitrogen as ammonia. once it matures into an adult, the frog spends more time on dry ground and

becomes ureotelic. which of the following enzyme activities would be the most likely to increase

drastically in the adult frog?: CPS I

6. aspartate aminotransferase: requires PLP

7. the reaction, glutamate + NAD(P)+ + H2O -> NH4+ + alpha-ketoglutarate + NAD(P)H + H+,

is catalyzed by : glutamate dehydrogenase (GDH)

8. which enzymes catalyze ATP-dependent reactions in the urea cycle?: -

arginosuccinate synthetase and CPS I

9. glutamine synthase activity is found highest in which compartment?: mus- cle tissue
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, BICH 411 Final Exam Review Questions and Answers

10.applies to ornithine transcarbamoylase: most common enzyme deficiency leading to urea

cycle disorder

11.in the alanine cycle, : pyruvate is the "energy" product of the cycle

12.what is true of the reaction catalyzed by glutamate dehydrogenase?: - NH4+ is produced

- the enzymes can use either NAD+ or NADP+ as a cofactor

- the enzyme is glutamate-specific

- beta-3-ketoglutarate is produced from an amino acid

13.what is the intermediate for arginosuccinate synthetase?: adenylated inter- mediate

14.what is used to excrete excess nitrogen by living organisms?: - ammonia

- urea

- uric acid

15.carbamate is the intermediate for what enzyme?: carbamoyl phosphate syn- thetase I




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