What are the neuromuscular conditions characterized by disruptions in neurologic and
autoimmune processes?
Myasthenia gravis
Alzheimer's disease
The medication classification administered for myasthenia gravis is
Acetylcholinesterase inhibitor
Medication classification administered for Alzheimer's disease
Medications related to improvement in memory
Acetylcholine:
T he neurotransmitter
Released at nerve endings
- Within the brain, it plays an important role in cognitive functions like memory storage
and retrieval.
- In the gut, this neurotransmitter stimulates normal secretory/motor activity.
- In the urinary system, it facilitates urination through muscle contraction or relaxation.
Myasthenia Gravis:
Chronic autoimmune neuromuscular disease
- Muscle weakness that increases during period of activity and improves after rest
- Results from defect in transmission of nerve impulses to muscles
Myasthenia crisis:
,Characterized by respiratory insufficiency, worsening of tongue and swallowing muscle
weakness, and rarely, respiratory failure
S/S of Myasthenia Gravis:
Drooping of one/both eyelids (ptosis)
Blurred or double vision (diplopia)
Unstable or waddling gait
Change in facial expression
Difficulty in chewing and swallowing
Shortness of breath
Impaired speech (dysarthria)
Weakness of arms, hands, fingers, legs, and neck
Myasthenia Gravis Drug Therapy:
Cholinergic drugs-stimulate PNS
Acytylcholinesterase-inhibitor drugs
Immunosuppressive Therapy
Prototype of Acetylcholinesterase-Inhibitor Drugs:
Neostigmine aka Pyridostigmine
, Immunosuppressive Therapy Drugs:
Azathioprine
Myocophenolate
Alzheimer's Disease:
Most common form of dementia
- Deficiency in cholinergic function of the cortex and basal forebrain
Early S/S of Alzheimer's Disease:
Forgetting newly learned information
Advanced S/S of Alzheimer's Disease:
Disorientation and mood/behavior changes; Deepening confusion about events;
Unfounded suspicions about family, friends, and professional caregivers; More serious
memory loss/behavior changes; Difficulty speaking, swallowing, and walking
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