1. What is the role of gastric secretions?
Answer
protection of pyloric mucosa
2. What do pyloric glands secrete?
Answer
mucus and gastrin
3. What is the gastric mucosal barrier?
Answer
tight junction in epithelial cell to prevent acid penetration, covered with hydrophobic lipid layer
4. What 2 things can cross the hydrophobic lipid layer?
Answer
alcohol and aspirin
5. What does the pancreas secrete to aid in digestion?
Answer
trypsin (breakdown dietary proteins)
pancreatic amylase (breaks down starch/lipases/triglycerides)
6. How does the gallbladder aid in digestion?
Answer
stores and concentrates bile (breaks down fats)
secretes bile through bile duct into duodenum (stimulated by entrance of food)
7. what is bile essential for?
Answer
fat digestion and absorption (emulsifies)
,8. what is the most common disorder of the esophagus?
Answer
GERD (gastroesophageal reflux disease)
9. what is the cause of GERD?
Answer
weak lower esophageal sphincter and increased intraabdominal pressure
10. manifestations of GERD
Answer
regurgitation (especially after meals) heartburn
pain or burning in retrosternal area (may radiate to shoulder or back) wheezing, cough,
hoarseness
11. What medications are used to treat GERD?
Answer
antacids H2 blocking agents
Proton pump inhibitors
12. How is GERD diagnosed?
Answer
hx of symptoms, xrays and scopes
13. GERD patient teaching
Answer
avoid large meals do not lie down after eating
avoid bending weight reduction
avoid aggravating foods sleep with head elevated
14. clinical manifestations of peptic ulcer disease (PUD)
Answer
burning, gnawing, cramplike pain in epigastric area (can radiate to back or shoulder)
, pain relieved with foods or antacids
15. complications of PUD
Answer
hemorrhage, perforation, hematemesis, melena (black tarry stools - blood from upper GI tract)
16. diagnostic tests for PUD
Answer
scopes and biopsy for H. pylori, barium, xrays, labs of hematocrit and hemoglobin
17. treatment for PUD
Answer
complete eradication of microorganisms (H. pylori) medications
Answer
PPI/H2RA/bismuth preparation
18. Risk factors for gastric ulcers
Answer
stress, trauma, severe illness, NSAID ingestion,
H. pylori, older adults over 60, smoking, warfarin, corticosteroids, family hx, caffeine, blood type
O (h. pylori attachment)
19. what type of ulcers are most common with PUD?
Answer
duodenal ulcers
20. Risk for duodenal ulcers
Answer
NSAID ingestion, H. pylori, any age/gender, chronic in nature, smoking
21. Causes of Irritable Bowel Syndrome
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