Intro to Biochemistry (Murphy 301) CH 1 – 4 Questions and Answers
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2024/2025
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2024/2025
Intro to Biochemistry (Murphy 301) CH
1 – 4 Questions and Answers
The side chain of histidine has a typical pKa value in the range of 6.5-7.4. However, when analyzing the
pKa values in a particular protein, scientists determined that one particular His residue has an unusually
low pKa value o...
Intro to Biochemistry (Murphy 301) CH
1 – 4 Questions and Answers
The side chain of histidine has a typical pKa value in the range of 6.5-7.4. However, when analyzing the
pKa values in a particular protein, scientists determined that one particular His residue has an unusually
low pKa value of 4.8. Which of the following statements correctly explain this anomaly?
1) The microenvironment around a residue can impact its pKa value.
2) A positively charged amino acid must be in close proximity to this residue.
3) A negatively charged amino acid must be in close proximity to this residue.
4) This residue must be located on the surface of the protein. - Ans:✔✔-Statement 1 and 2
The side chain of ________ has a pKa in the physiological pH range and is therefore often involved in
proton transfer during enzymatic catalysis. - Ans:✔✔-Histidine
All amino acids have a chiral α-carbon EXCEPT ________. - Ans:✔✔-glycine
All amino acids except _______ are chiral with the two isomer forms known as the L-isomer and the D-
isomer. - Ans:✔✔-glycine
The ____ is the only isomer known to be incorporated into proteins. - Ans:✔✔-L-isomer
This ionic state, where the carboxylic acid is negative and the amine group is positive, is known as the
__________ state - Ans:✔✔-zwitterionic state
What are the N-terminal and C-terminal residues for the following peptide sequence?
Peptide sequence: EASY - Ans:✔✔-E is the N-terminal residue; Y is the C-terminal residue.
Ultimate source of energy for life on earth is:
A. Sun
B. Geothermal heat
C. Carbohydrates
D. Fats
E. Other organisms - Ans:✔✔-Sun
Which is not a common component of biomolecules?
A. Carbon
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