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AACN AGACNP Review A+ Guide Questions and Answers
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AACN AGACNP Review A+ GuideQuestions and Answers 2024-2025
Cushing's Syndrome/Disease - correct answer
✅✅cortisol excess typically caused by pituitary
adenoma 60-70% of cases.
Central obesity w/ extremity wasting.
dorsocervical fat pad.
rounded facies.
spontaneous bruising.
purple striae
hyperpigmentation
poor wound healing/ skin infections.
Dexamethasone suppression test.
1mg dexamethasone at 2300 hours and measure serum
cortisol at 0800.
Remove sources of excess and manage consequences
( HTN, hypokalemia, hyperglycemia.)
Addison's disease - correct answer ✅✅Primary
, AACN AGACNP Review A+ Guide
Questions and Answers 2024-2025
Caused by damage to the adrenal cortex (autoimmune,
TB, metastatic disease, deposition diseases, and drug
induced) leading to a decrease in cortisol production.
Secondary
Caused by pituitary failure to release ACTH (in any
hypopituitary disorder) causing a decrease in cortisol
production.
Sudden withdrawal of systemic corticosteroids leading to
a decrease in cortisol production from induced
corticosteroid suppression.
diabetes insipidus (DI) - correct answer ✅✅Insufficient
ADH or decreased sensitivity to ADH
Nephron cannot conserve water.
Commonly caused by damage to the pituitary gland or
hypothalamus (surgery, tumor, meningitis, head injury).
Can be nephrogenic where the kidney in unable to
respond to ADH.
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