PCOL 838b EXAM 1
MHC Class I - Answer- display antigens from intracellular pathogens
interact with CD8
expressed on ALL cells
MCH Class II - Answer- display antigens from extracellular pathogens.
interact with CD4
expressed on APCs
humoral immunity - Answer- antibody-med...
PCOL 838b EXAM 1
MHC Class I - Answer- display antigens from intracellular pathogens
interact with CD8
expressed on ALL cells
MCH Class II - Answer- display antigens from extracellular pathogens.
interact with CD4
expressed on APCs
humoral immunity - Answer- antibody-mediated immunity
involves B cells
cell-mediated immunity - Answer- type of immunity produced by T cells that attack infected or abnormal body cells
isotype of antibody - Answer- determined by constant region of heavy chain
somatic recombination - Answer- gene segments of antibody rearrange to form variable domain gene
junctional diversity - Answer- source of antibody diversity
RAG yields DNA hairpin which is then cleaved, TdT adds nucleotides at random, gaps filled by DNA synthesis
isotope class switching - Answer- VDJ region is brought to a new constant region of the heavy chain
heavy chain constant region determined by cytokines
constant region=isotype
isotype class switching signals - Answer- 1. CD40 ligand (on T cell) interacts with CD40 on B cell
2. Cytokine determines isotype class
memory B cell formation - Answer- 1. B cell interacts with T cell via antigen-MHC and CD40-CD40 L
2. Cytokine released from T cell
-IL-10 forms plasma cells; IL-4 forms memory cells (IgG antibodies)
chemokine receptors - Answer- GPCRs
cytokine IL-2, IL-15, IL-4 receptors - Answer- share one common gamma chain
NBT test - Answer- nitro blue tetrazolium used to test macrophage function
if macrophage does not turn blue = inactive
X-linked agamma globulinemia - Answer- loss of Btk tyrosinekinase
NO B cell formation
chromones - Answer- stabilize mast cell to prevent granule release
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