NSG 511 EXAM 2
Acetylsalicylic Acid (Aspirin) - Answer- 1st Gen NSAID - COX 1 and COX 2 inhibitor
MI and Stroke Prophylaxis, analgesic, antipyretic, anti-inflammatory
SE: Salicylism, tinnitus, headache, dizziness
Contraindication: Gastric Ulceration, increased risk of bleeding
Ibuprofen (Advil, Motrin) - Answer- 1st Gen NSAID - COX 1 and COX 2 inhibitor
Analgesic, antipyretic, anti-inflammatory
SE: Salicylism, tinnitus, headache, dizziness
Contraindication: Gastric Ulceration, increased risk of bleeding
Naproxen - Answer- 1st Gen NSAID - COX 1 and COX 2 inhibitor
Analgesic, antipyretic, anti-inflammatory
SE: Salicylism, tinnitus, headache, dizziness
Contraindication: Gastric Ulceration, increased risk of bleeding
Ketorolac (Toradol) - Answer- 1st Gen NSAID - COX 1 and COX 2 inhibitor
Acute Pain, Short term, Anti-inflammatory, analgesic, antipyretic
SE: Serious GI side effects
Notes: Do not use >5 days - metabolized in liver - excreted in kidneys
Celecoxib (Celebrex) - Answer- 2nd Gen NSAID - COX 2 inhibitor
Used for Arthritic pain
SE: Gastroduodenal ulceration, cardiovascular events, renal impairment
Interactions: Warfarin - can increase blood levels of warfarin - patients at risk for MI,
stroke, CVD
Acetaminophen (Tylenol) - Answer- Non-aspirin pain reliever (NOT NSAID)
Analgesic, antipyretic
SE: Acute liver toxicity
, Avoid alcohol, can increase warfarin in blood, vaccines
Morphine - Answer- Opioid agonist - Mu and Kappa receptor agonist
Analgesic
SE: Sedation, euphoria, respiratory depression, cough suppression, suppression of
bowel motility
AE: Respiratory depression, constipation, orthostatic HTN, urinary retention, cough
suppression, N and V emesis, euphoria, dysphoria, sedation, and birth defects
Notes: Small fraction crosses BBB, inactivated in first pass - tolerance and physical
dependence, abstinence syndrome
Interactions: Interactions: CNS depressants, benzodiazepines, anticholinergics,
antihistamines, hypotensive drugs, other opioids, opioid agonist, opioid antagonists
Pentazocine - Answer- Opioid agonist-antagonist - Mu antagonist - Kappa agonist
Less powerful analgesic (Mild to Moderate pain)
SE: Abstinence syndrome (less potential for addiction), less sedation, less
respiratory depression, dizziness, headache, and making the heart work harder
Interactions: Avoid CNS depressants, alcohol, opioid agonist
Buprenorphine - Answer- Opioid agonist-antagonist - partial agonist at Mu receptors
and antagonism at Kappa - can precipitate withdrawal
Analgesic, used to treat opioid addiction
SE: Abstinence delayed, prolonged QT interval
Interactions: Avoid CNS depressants, alcohol, opioid agonist
Naloxone (Narcan) - Answer- Opioid antagonist - reverses CNS depression
Treatment of opioid related issues - respiratory depression, constipation (severe),
opioid OD
No effect in the absence of opioids
Adverse: Tachycardia, tachypnea, abstinence syndrome or acute withdrawal
Naltrexone - Answer- Opioid antagonist
Opioid and alcohol abuse - used to reduce ethanol craving
