VTA, SN - Answers Cell bodies for dopamine neurons located mainly
Raphe nucleus - Answers Cell bodies for serotonergic neurons located
Locus ceruleus - Answers Cell bodies for noradrenergic neurons located
Positive allosteric modulation, binding to ion channels activated by GABA, enhancing effect of GABA on
channel conductance , GABA-A receptor - Answers Exact mechanism of benzos
Doxepin - Answers Most anticholinergic TCA
Desipramine - Answers Least anticholinergic TCA
2D6, 1A2 (to lesser extent) - Answers Main CYP involved in TCA metabolism
Nortriptyline - Answers Active metabolite of amitriptyline
1A2 - Answers Enzyme (CYP) converting amitriptyline to active metabolite
TCAs - Answers Class of medication that inhibits antihypertensive effects of clonidine
, NE and dopamine reuptake inhibition and stimulation of release (mostly of dopamine) - Answers
Mechanism of amphetamine stimulants
3A4, 2D6 - Answers CYP involved in metabolism of aripiprazole
NE reuptake inhibition, possible increase in dopamine - Answers Mechanism of action of atomoxetine
2D6 - Answers CYP involved in metabolism of atomoxetine
3A4 (+ auto induction) - Answers CYP involved in metabolism of carbamazepine
3A4 and 2C19 - Answers CYP involved in metabolism of citalopram
1A2, 3A4, 2D6 - Answers CYP involved in metabolism of clozapine
NE reuptake inhibition, blocks dopamine transporter - Answers Mechanism of action of bupropion
Action on voltage-sensitive sodium channels and inhibition of glutamate release - Answers Mechanism
of action of carbamazepine
Alpha-2 agonist (post synaptic) - Answers Mechanism of action of clonidine
Blocks benzodiazepine receptor at GABA-A ligand-gated chloride channel complex (competitive
antagonism) - Answers Mechanism of action of flumazenil
Inh 2D6 - Answers CYP inhibited/induced by bupropion
Induces 3A4 (auto induction) - Answers CYP inhibited/induced by carbamazepine
Inh 2D6 and 3A4 - Answers CYP inhibited/induced by fluoxetine
Induces 3A4 - Answers CYP inhibited/induced by St-John's wort
Opioids, THC, GHB - Answers Substance of abuse with effect on GPCR receptors
Benzodiazepines, nicotine, alcohol - Answers Substance of abuse with effect on ion channels
Selective agonism of nicotinic acetylcholine receptor (these receptors are located on dopamine neurons
in the VTA and dopamine is released in the nucleus accumbens ) - Answers Mechanism of nicotine
Reexposure to the drug, stress, exposure to cues associated with drug - Answers Triggers for substance
relapse
5HT-2A agonism - Answers Mechanism of action LSD
NMDA antagonist - Answers Mechanism of action PCP
Presynaptic inhibition of GABA neurons by CB1 agonism, causing disinhibition of dopamine neurons -
Answers Mechanism of THC on dopamine
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