Psychopharm PEARLS 2 Review Questions with Complete Solutions Rated A+
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Psychopharm PEARLS 2
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Psychopharm PEARLS 2
Psychopharm PEARLS 2 Review Questions with Complete Solutions Rated A+
Retrograde neurotransmissions refers to? - Answers The flow of neurotransmitter from postsynaptic neuron to presynaptic neuron
Use the following CYP450 table to hypothesize drug interactions and their clinical significance for...
Psychopharm PEARLS 2 Review Questions with Complete Solutions Rated A+
Retrograde neurotransmissions refers to? - Answers The flow of neurotransmitter from postsynaptic
neuron to presynaptic neuron
Use the following CYP450 table to hypothesize drug interactions and their clinical significance for a
patient on clozapine who carbamazepine, a mood stabilizer? - Answers Clozapine levels would decrease,
placing the patient at risk for re-emergence of psychotic symptoms.
In ligand-gated ion channels, an? - Answers Antagonist, in the presence of an agonist, can return a
channel to resting state.
Which of the following statements about drug absorption is trued? - Answers Concurrent use of some
medications can slow absorption.
A neurotransmitter binds to a receptor, causing electrical impulses to travel the neuron's axon; it
eventually releases the neurotransmitter and repeats the process with a postsynaptic neuron. Which
type of neurotransmission does this describe? - Answers Classic synaptic neurotransmission
Which of the following statements is true about drug distribution? - Answers Protein binding of
psychotropic drugs can impact their availability at receptor sites
First pass effect refers to the? - Answers Metabolism of the drug in the liver, prior to reaching systemic
circulation
Pharmacodynamics - Answers Action of drugs on the body
Pharmacokinetics- - Answers Action of the body on the drugs
axon - Answers The fiber-like part of the neuron that sends information to receiving neurons
Ionic filter - Answers Regulates the flow of ions in ligand-gated channels
Excitation-secretion coupling - Answers The conversion of an electrical signal to a chemical signal
Dendrite - Answers The point of contact for receiving information from neurons in the classical
Use the following CYP450 table to hypothesize drug interactions and their clinical significance for a
patient on haloperidol, a conventional antipsychotic, who is prescribed paroxetine, an antidepressant? -
Answers Haloperidol levels would increase, placing the patient at risk for antipsychotic side effects
Which of the following statements is true about ligand-gated ion channels? - Answers Allosteric
modulators can enhance or inhibit ion channels when in the presence of neurotransmitter
Which of the following statements about pharmacokinetics is true? - Answers Accumulation of
psychotropic drugs occurs faster in the brain then adipose tissue.
G-linked proteins? - Answers Bind enzymes that synthesize second messengers.
, Carbamazepine has a half-life of approximately 12 hours. The clinical implications of this are? - Answers
Therapeutic blood monitoring of carbamazepine should not occur before 2 ½ days of starting the
medication
When an inverse agonist binds to a G-protein linked receptor, signal transduction is? - Answers
Inactivated
. When an antagonist binds to a G-protein-linked receptor, signal transduction is? - Answers Unchanged
. When an agonist binds to a G-protein-linked receptor, signal transduction is? - Answers Fully enhanced.
When a partial agonist binds to a G-protein-linked receptor, signal transduction is? - Answers Partially
enhanced
When prescribing atypical antipsychotic medications, it is important to consider which of the following?
- Answers Atypical antipsychotics are not approved for the treatment of geriatric dementia-related
psychosis and carry increased risk of mortality in this population
Atypical antipsychotics, also known as second-generation antipsychotics, are related to as atypical
because? - Answers They have the clinical profile of equal positive symptom antipsychotic actions but
low extrapyramidal symptoms and less hyperprolactinemia compared to conventional antipsychotics
Which of the following statement is true regarding cognitive symptoms of psychosis? - Answers
Cognitive symptoms are the strongest correlate of real-world functioning in schizophrenia.
Histamine H1 receptor blockade- - Answers Weight gain and drowsiness
Alpha-1 adrenergic receptor blockade - Answers Orthostatic hypotension and drowsiness
Which of the following statement is true about conventional antipsychotics? - Answers Conventional
antipsychotics are thought to block dopamine at the D2 receptor equally in dopamine neural circuits.
Which of the following statement is true about tardive dyskinesia? - Answers Elderly patients may
develop tardive dyskinesia sooner in treatment than younger patients
When considering metabolic risk associated with atypical antipsychotics which of the following
statements is true? - Answers Patients taking atypical antipsychotics are at increased risk for diabetes
and cardiovascular disease.
Which of the following statements best describes the nigrostriatal dopamine pathway? - Answers
Chronic blockade of D2 receptors in the nigrostriatal dopamine pathway may result in tardive
dyskinesia.
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