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Pharm Tox Exam Questions with Correct Answers (A Graded)
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Pharm Tox Exam Questions with CorrectAnswers (A Graded)
The patient presented by Dr. Hooten was on several drugs from the referring medical doctor.
Which one of the following is INCORRECT as it relates to the drug and the rationale behind
prescribing this drug.
a. Orinase (tolbutamide) - because the associated hypoglycemia
b. Zantac (ranitidine) - because of the increase in gastric acid production
c. Slow-K (potassium chloride) - because of the hypokalemia
d. Bumex (bumetanide) - because of the hypernatremia and subsequent pedal edema
e. Dexamethasone - because of its immunosuppressive effects - ANSWER a. Orinase
(tolbutamide) - because the associated hypoglycemia
Which of the following is NOT considered a physiologic effect of glucocorticoids?
a. promote the breakdown of glycogen releasing glucose into the blood stream
b. increase lipolysis/catabolism of fats in adipose tissues thereby increasing circulating levels of
free fatty acids
c. increase amino acid release from muscle catabolism to go to liver to make glucose
thereby increasing the urea load on the kidney and elevating the BUN
d. they have a catabolic effect upon bone, decrease osteoblastic activity and antagonize the
effects of Vit. D on calcium absorption from the gut
e. they increase circulating neutrophil numbers by decreasing the peripheral vascular
margination of neutrophils - ANSWER e. they increase circulating neutrophil numbers
by decreasing the peripheral vascular margination of neutrophils
Choose the INCORRECT statement.
,a. Chronic Vit A toxicity can cause the following signs: headache, fatigue (but difficulty
sleeping), visual disturbances, anorexia, weight loss, increased intracranial pressure, dry
skin that is pruritic and scaly and peeling; hair loss; brittle nails; cheilitis, gingivitis and
stomatitis; hepatomegaly, nausea, abdominal pain and ascites
b. Vitamin D deficiency manifests as osteomalacia in growing children and rickets in
adults-(Vise versa)
c. Vit K is essential cofactors in the hepatic biosynthesis of blood coagulation factors II, VII, IX,
and X d. Humans, guinea pigs and the Indian fruit bat are the mammals who cannot
synthesize Vit C from glucose
e. Functions of Vit. E - necessary for normal reproduction and neuromuscular function, also
important as an antioxidant - ANSWER b. Vitamin D deficiency manifests as osteomalacia
in growing children and rickets in adults- (Vise versa)
Choose the INCORRECT match of disease that would be associated with prolonged
physiologic effect of glucocorticoids listed.
a. peptic ulcers - due to increase gastric acid and pepsin release by the stomach
b. hypertension - due to peripheral vasoconstriction, increase circulating RBC numbers,
increase circulating platelets, increase cardiac output
c. pedal edema - due to retention of sodium
d. osteoporosis - due to decrease osteoblastic activity, antagonize the effects of Vit. D on
calcium absorption from the gut
e. Cushing's syndrome - due to pituitary adenoma secreting too much ACTH and subsequent
elevation of glucocorticoids in the blood stream - ANSWER e. Cushing's syndrome - due to
,pituitary adenoma secreting too much ACTH and subsequent elevation of glucocorticoids in the
blood stream: Should be to low
Analgesic nephropathy with an associated papillary necrosis is a common complication of:
a. acute overdose with Aspirin
b. acute overdose with Acetaminophen
c. acute overdose with combination of Aspirin and Ibuprofen (Motrin)
d. chronic use of Ibuprofen (Motrin)
e. chronic use of combination of Aspirin and Acetaminophen (Tylenol) - ANSWER chronic use of
combination of Aspirin and Acetaminophen (Tylenol)
Which of the following signs and symptoms is DOES NOT make sense with those seen in a
patient with Cushing's syndrome?
a. polydipsia - associated with blood glucose levels in excess of 180mg%
b. buffalo hump - associated with cervico-dorsal fat redistribution
c. thinning of extremities - associated with increase amino acid release from muscle and muscle
atrophy
d. increased immune competency - associated with elevated levels of circulating neutrophils
e. thinning of dermis - associated with inhibition of protein synthesis and inhibition of
fibroblastic growth - ANSWER a. polydipsia - associated with blood glucose levels in excess of
180mg%
Sympathetic amines used as bronchodilators stimulate _____ receptors?
a. Alpha one
, b. Beta one
c. Beta two
d. R2D2 - ANSWER Beta two
A tincture is prepared differently than a decoction in that the active ingredients in a tincture
are extracted by soaking the herb in _____.
a. Boiling water
b. Alcohol
c. Cold water
d. Turpentine - ANSWER Alcohol
A patient comes to your clinic and you order blood tests. Of the following hematological
parameters, which one would be consistent with a patient who is taking exogenous
glucocorticoids?
a. Anemia (decrease RBC's)
b. Hypoglycemia
c. Neutropenia (decrease circulating neutrophil numbers)
d. Eosinophilia (increase circulating number of eosinophils)
e. Lymphopenia (decrease in the number of circulating lymphocytes) - ANSWER Lymphopenia
(decrease in the number of circulating lymphocytes)
Which of the following describes the clinical effects of n-Acetylcysteine (Mucomyst)?
a. Mucolytic agent
b. Stimulates beta receptors in bronchial airways
c. Used in aspirin overdose to inhibit prostaglandin production
d. Is a steroidal agent used to control synthesis of inflammatory mediators
e. Both A and C are correct - ANSWER e. Both A and C are correct
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