NU 641 GOUT medications Exam Questions and Answers
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Course
2024/2025
Institution
2024/2025
NU 641 GOUT medications Exam
Questions and Answers
Is gout a form of arthritis? What happens in gout? - Answer-Yes. It is considered a form of
arthritis.
In gout, purine metabolism is altered leading to increased uric acid
Hyperuricemia
Urate Crystals deposit in joints, tendons and surroundin...
What are the names of three medications that are considered antigout? Why are they
considered antigount? - Answer✔✔-Allopurinol (Zyloprim)
Febuxostate (Uloric)
Colchicine (Colcrys)
All these drugs decrease uric acid
Allopurinol and Febuxostat inhibit xanthine oxidase - enzyme responsible for conversion to uric
acid.
Only drugs that act directly on the pathophysiological cause of gout.
Colchicine does not affect purine metabolism but
Inhibits migration of granulocytes to the inflamed area.
It Reduces lactic acid production by granulocytes which decreases deposition of uric acid
How Allopurinol is different than Febuxostat - Answer✔✔-Both act directly on purine
metabolism, reducing uric acid production
With Allopurinol Serum and urine uric acid starts to fall in 2 to 3 days (quicker than Febuxostat) -
may be week or more before full effect
Febuxostat may take 2 weeks or more to see effect
What does Colchicine do in gout? - Answer✔✔-Decreases inflammatory response of acute gout
Relieves pain in acute attacks - not analgesic
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