Difference Principle - ✔✔*The second of Rawls two principles of justice: "Social and
economic inequalities should be arranged so they are both:
A) The greatest benefit of the least advantaged person and,
B) Attached to offices and positions open to all under conditions of equality of opportunity."
Consent - ✔✔To permit, approve, or agree; comply or yield
Assent - ✔✔To give in, to agree or to cooperate (to concur)
Clinical Trial Phases - ✔✔Phase I: small number of people (10-80 ppl), evaluate safety, identify
side effects, determine safe dose. aim of he trial is NOT to test the effectiveness of the therapy
Pase II: investigators test the treatment (100-300 ppl) to determine whether the therapy is
effective and to further test its safety. Safety and effectiveness measured
Phase III: Investigators test the therapy in a larger number (1000-3000 ppl) to confirm its
effectiveness, montor side effects, compare to accepted therapies & collect data
Phase IV: Investigators college data about the therapy's side effects after the therapy has
become established as a standard treatment. Aim is to refine the use of therapy and
improve safety
*Phase I= healthy human volunteers, Phase II= patients who might be expected to benefit
from it
, Informed Consent - ✔✔*No more than agreement "yes"
*Valid consent requires that we deliberate before we decide- both information
and understanding
*Some people say, *** is at worst a pointless charade and at best a polite fiction
*Painents must understand enough about the proposed research and treatment to
deliberate and reach a decision, make it valid
Placebos - ✔✔*In informed consent they are considered essential to determine the true
effectiveness of the drug being tested.. they aren't receiving the best available treatment
*Still have side effects= nervousness, vomiting, loss of appetite, etc.
*Investigators can still test a treatment with known side affects/ what happens with a
new treatment with a possible but not proven effectiveness
Children Consent - ✔✔* Lack phsyical, psychological, and intellectual maturity, nutritional
needs are different, prone to certan types of diseases, suffer diferently from adults in
many treatments, rely a lot on parents
*Parental Consent= what age is a child
*Therapeutic Benefits
*Guidelines- permission, responsibility, supplied with an "advocate" to represent her and his
interest
Children and Placebos - ✔✔*Some children will not receive medical care considered to be
the best. A child who is a subject in such research is then put in a situation in which he or she
is subjected to definite hazard.
*Consequence of doing this would be to restrict the development of new and potentially
more effective medications and treatment techniques- future generations of children would
be deprived of at least some possible medical advances
Paternalism - ✔✔*The view that people often need to be protected from themselves or
their own decisions.
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