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PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE UNIVERSITY).pdf
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PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE UNIVERSITY).pdf
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lOMoAR cPSD| 22896205PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE
UNIVERSITY)
PHARMACOLOGY EXAM 2 STUDY GUIDE CNS
PHARMACOLOGY PHARMACOTHERAPEUTICS
(MARYVILLE UNIVERSITY)
Nearly all drugs with CNS effects act on specific receptors that modulate synaptic transmission
Neurotrans
mitters o
Epinephrine
fight or flight
o Norepinephrine
concentration (levels of activity, alertness, appetite, sleep patterns)
o Dopamine
pleasure (sleep, sexual behavior, anxiety/agitation, euphoria, addictions)
o Serotonin
mood (anxiety, sexual behavior, appetite, aggression, pain, obsessions, emesis, learning,
psychosis, migraine, sleep, suicidal ideation)
o GABA o Acetylcholine
learning
& memory o
Glutamate
memory o
Endorphins
euphoria
CNS Drugs
PHARMACOLOGY EXAM 2 STUDY GUIDE |
, lOMoAR cPSD| 22896205
PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE
UNIVERSITY)
o -bital barbiturate (sedative) butobarbital, phenobarbital,
secobarbital
o -pramine tricyclic antidepressant (TCA) clomipramine, desipramine,
imipramine
o -triptyline TCA amitriptyline, nortriptyline
o -ridone atypical antipsychotic iloperidone, risperidone,
paliperidone
o -azepam benzodiazepine clonazepam, diazepam, lorazepam
o -zolam benzodiazepine alprazolam, midazolam, triazolam
o zodone antidepressant nefazodone, trazodone, vilazodone
o -ine antidepressant fluoxetine, sertraline, SSRIs
o -triptan migraines sumatriptan, naratriptan,
almotriptan
Anticonvulsants
• Block transmission and raise seizure threshold
• Require a certain therapeutic level to work consistently; frequent blood work
Drug level, CBC (Tegretol can cause agranulocytosis), TSH (meds can affect the thyroid)
• Take on regular basis at the same time every day
• Patient safety—driving limitations, heavy machinery operation, etc. Increase need for oral care
• Topiramate (Topamax)
Monitor serum can cause low serum bicarb = hyperchloremic
bicarb metabolic acidosis
MOA: Blocks
NA channel; potentiates GABA
• Levetiracetam (Keppra)
PHARMACOLOGY EXAM 2 STUDY GUIDE |
, lOMoAR cPSD| 22896205
PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE
UNIVERSITY)
Do not abruptly discontinue
MOA: binds to protein SV2A
Safer in pregnancy
• Carbamazepine (Tegretol)
CBC every 3
months
Risk for agranulocytosis, anemia
MOA: blocks Na+ channels
• Valproate (Depakote)
Do not take while
pregnant
MOA: increase GABA in the brain by blocking reuptake
PHARMACOLOGY EXAM 2 STUDY GUIDE |
, lOMoAR cPSD| 22896205
PHARMACOLOGY EXAM 2 STUDY GUIDE CNS PHARMACOLOGY PHARMACOTHERAPEUTICS (MARYVILLE
UNIVERSITY)
Drug MOA Side Effects Monitoring Pt. Teaching
Topiramate (Topamax) Block Na+ channel; Ocular syndrome ↓serum bicarb. (hyper-
Inform of eye problems potentiates GABA Oligohydramnios, chloremic
met.acidosis hyperthermia
PHARMACOLOGY EXAM 2 STUDY GUIDE |
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