ASCP CGMBS Exam Study Questions and Answers 2024/2025
3 views 0 purchase
Course
ASCP CGMBS
Institution
ASCP CGMBS
BCR;ABL1 fusion protein
→ t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL)
→ t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma
→ t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the CMY C gene
Follicular Cell Lymphoma (FCL)
→ t(14;18) translocatio...
ASCP CGMBS Exam Study Questions and
Answers 2024/2025
BCR;ABL1 fusion protein
→ t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL)
→ t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma
→ t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the C-
MY C gene
Follicular Cell Lymphoma (FCL)
→ t(14;18) translocation disregulate BCL2, which inhibits apoptosis in B lymphocytes,
which leads to survival of genetically damaged cells
Mantle Cell (MCL)
→ t(11;14) translocation increases expression of CCND1
Chronic Myelogenous Leukemia (CML)
→ t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the
breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson
Leukemia virus tyrosine kinase (c-abl) on chr.9
→ second-line drug for cutaneous T-cell lymphoma. Treatments are often used in
combination with phototherapy and chemotherapy
Irinotecan
→ UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1
Warfarin (Coumadin)
→ CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in
the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein
vitamin epoxide reductase complex, subunit 1 (VKORC1)
Tamoxifen
→ CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in pre-
menopausal women
Azathioprine
→ TPMT - immunosuppresive used in organ transplant
Carbamazepine
→ Ineffective to HLA B1502
Plavix
→ CYP2C19 - anticoagulant (stroke, heart attack)
Herceptin
→ HER2/Neu - anti Her2/neu
1|Page| GradeA+ | 2 0 0 2 5
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TestTrackers. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.49. You're not tied to anything after your purchase.
