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Pathoma-Questions and Answers 100% Solved
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Pathoma-Questions and Answers 100% Solved
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Pathoma-Questions and Answers 100% SolvedHeparin-Induced Thrombocytopenia Correct Ans-Platelet destruction that arises secondary
to heparin therapy
Disseminated Intravascular Coagulation (DIC) Correct Ans-Pathologic activation of the
coagulation cascade
Anemia Correct Ans-Disruption in circulating red blood cell (RBC) mass
Anemia of Chronic Disease Correct Ans-Anemia associated with chronic inflammation or
cancer
Iron Deficiency Anemia Correct Ans-Anemia due to decreased levels of iron
Sideroblastic Anemia Correct Ans-Anemia due to defective protoporphyrin synthesis
Thalassemia Correct Ans-Anemia due to decreased synthesis of the globin chains of
hemoglobin
Megaloblastic Anemia Correct Ans-Anemia due to folate or vitamin B12 deficiency
, Pathoma-Questions and Answers 100% Solved
Hereditary Spherocytosis Correct Ans-Inherited defect of RBC cytoskeleton-membrane
tethering proteins
Sickle Cell Anemia Correct Ans-Autosomal recessive mutation in beta chain of hemoglobin;
a single amino acid change replaces normal glutamic acid (hydrophilic) with valine
(hydrophobic)
Paroxysmal Nocturnal Hemoglobinuria (PNH) Correct Ans-Acquired defect in myeloid stem
cells resulting in absent glycosylphosphatidylinositol (GPI); renders cells susceptible to
destruction by complement
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency Correct Ans-X-linked recessive
disorder resulting in reduced half-life of G6PD; renders cells susceptible to oxidative stress
Immune Hemolytic Anemia Correct Ans-Antibody-mediated (IgG or IgM) destruction of
RBCs
Microangiopathic Hemolytic Anemia Correct Ans-Intravascular hemolysis that results from
vascular pathology; RBCs are destroyed as they pass through the circulation
Malaria Correct Ans-Infection of RBCs and liver with Plasmodium; transmitted by the
female Anopheles mosquito
, Pathoma-Questions and Answers 100% Solved
Parvovirus B19 Correct Ans-Infects progenitor red cells and temporarily halts
erythropoiesis; leads to significant anemia in the setting of preexisting marrow stress (e.g.,
sickle cell anemia)
Aplastic Anemia Correct Ans-Damage to hematopoietic stem cells, resulting in
pancytopenia (anemia, thromobocytopenia, and leukopenia) with low reticulocyte count
Infectious Mononucleosis Correct Ans-EBV infection that results in a lymphocytic
leukocytosis comprised of reactive CD8+ T cells; CMV is a less common cause
Acute Lymphoblastic Leukemia (ALL) Correct Ans-Neoplastic accumulation of lymphoblasts
(>20%) in the bone marrow
Acute Myeloid Leukemia (AML) Correct Ans-Neoplastic accumulation of myeloblasts
(>20%) in the bone marrow
Chronic Lymphocytic Leukemia (CLL) Correct Ans-Neoplastic proliferation of naive B cells
that co-express CD5 and CD20
Hairy Cell Leukemia Correct Ans-Neoplastic proliferation of mature B cells characterized by
hairy cytoplasmic processes
, Pathoma-Questions and Answers 100% Solved
Adult T-Cell Leukemia/Lymphoma (ATLL) Correct Ans-Neoplastic proliferation of mature
CD4+ T cells
Mycosis Fungoides Correct Ans-Neoplastic proliferation of mature CD4+ T cells that
infiltrate the skin, producing localized skin rash, plaques, and nodules
Chronic Myeloid Leukemia (CML) Correct Ans-Neoplastic proliferation of mature myeloid
cells, especially granulocytes and their precursors; basophils are characteristically increased
Polycythemia Vera (PV) Correct Ans-Neoplastic proliferation of mature myeloid cells,
especially RBCs
Essential Thrombocytopenia Correct Ans-Neoplastic proliferation of mature myeloid cells,
especially platelets
Myelofibrosis Correct Ans-Neoplastic proliferation of mature myeloid cells, especially
megakaryocytes
Follicular Lymphoma Correct Ans-Neoplastic proliferation of small B cells (CD20+) that
form follicle-like nodules
Mantle Cell Lymphoma Correct Ans-Neoplastic proliferation of small B cells (CD20+) that
expands the mantle zone
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