Exam (elaborations)
Pathoma: Hemostasis and Related Disorders Test with Solutions
- Course
- Institution
Pathoma: Hemostasis and Related Disorders Test with Solutions
[Show more]
Content preview
Pathoma: Hemostasis and Related Disorders Test withSolutions
idiopathic thrombocytopenic purpura: IgG Correct Ans-they are produced by plasma cells
in the spleen
then, the Ab bound platelets are alter consumed by the macrophages in the spleen
idiopathic thrombocytopenic purpura: forms Correct Ans-acute
- think children
chronic
- think adults, think ppl with AI disease
idiopathic thrombocytopenic purpura: acute form Correct Ans-children
1. thrombocytopenia weeks after infection or immunization
2. self0limiting d/o within weeks of pt
Tx: support, esp. with really bad thrombocytopenia
idiopathic thrombocytopenic purpura: chronic form Correct Ans-1. usually F of child
bearing age
2. may be primary or secondary
, Pathoma: Hemostasis and Related Disorders Test with
Solutions
idiopathic thrombocytopenic purpura: pregnant women Correct Ans-may cause a short
lived thrombocytopenia in the offspring
0 this is due to the fact that the anti platelet IgG can cross the placenta; this is something to
look out for with women with lupus
idiopathic thrombocytopenic purpura: labs Correct Ans-1. decreased platelets
2. PT/PTT norma; this is bc the coagulation cascade is not affected
3. increase int he megakaryocytes in the bone marrow;
- body senses low platlets
- attempt at compensation
idiopathic thrombocytopenic purpura: Tx Correct Ans-1. corticosteroids
- works hella good in acute
- relapse common in the chrnoic form
2. IVIG:
- short lived tx for serious bleeding concern
- decoy for the splenic macrophages such that they are overwhelmed consuming the IVIG and
are thus less likely to be chomping on an IgG-bound platelet
3. for refractory cases: splenectomy
, Pathoma: Hemostasis and Related Disorders Test with
Solutions
- eliminates both the source of the Ab and the source of the site of destruction
Microangiopathic hemolytic anemia: what it do Correct Ans-formation of small thrombi
that cause stress on RBCs, shearing them and causing the formation of both schistocytes and
anemia
Microangiopathic hemolytic anemia: why talk about it here? Correct Ans-due to the
microthrombi that form (made only of platelets), there is consumption of a lot of platelets
throughout the tissues.
this leads to a thrombocytopenia
schistocyte Correct Ans-helmet cells
Microangiopathic hemolytic anemia: two diseases Correct Ans-1. TTP- thrombotic
thrombocytopenic purpura
2. HUS - hemolytic uremic syndrome
TTP: what it do? Correct Ans-platelet microthrombi form due to a deficiency or decrease in
the amount of Adams Ts protein
TTP: adams ts 13 Correct Ans-protein that is needed to cleave multimers of vWF that are
produced in order to get the active form of this
, Pathoma: Hemostasis and Related Disorders Test with
Solutions
the multimeric form then piles up and leads to abnormal adhesion (Gp1B to vWF) leading to
the microthrombi
TTP: what causes the adams ts 13 decrease Correct Ans-1. can be a genetic defect but
2. autoantibody production against the protein
TTP: who Correct Ans-adult females with an AI process such as lupus
HUS: what is it Correct Ans-endothelial damage to the blood vessels classically by drugs or
infections leads to microthrombi formation
- this leads to consumption of platelets and thrombocytopenia
- this also causes schistocytes to develop
anemia + decrease in the renal blood flow --> risk of renal damage and acute renal failure
HUS: how to get it Correct Ans-children who are exposed to the undercooked beef
- E coli 015787
-- verotoxin leads to endothelial damage resulting in
-- dysentery
-- renal issues primarily
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller TheeGrades. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
77254 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now