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BMS 602 Mycobacterium Tuberculosis Exam Studty Set
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BMS 602 Mycobacterium TuberculosisExam Studty Set
describe Mycobacterium spp. - Answer non motile, non spore forming, aerobic rods,
neither gram negative or positive, generally slow growers in vitro
describe Mycobacterium spp. cell wall - Answer very hydrophobic, peptidoglycan layer
linked to arabinogalactan, mycolic acid layer overlaid with lipis, glycolipids,
peptidoglycolipids and proteins
what was tuberculosis also know as? - Answer great white plague
M. tuberculosis pathogen - Answer acid fast, slow growing, rod
M. tuberculosis encounter - Answer human reservoir (humans are natural reservoir)
M. tuberculosis entry - Answer human to human spread via inhalation of contaminated
respiratory secretions from infected individual
M. tuberculosis spread - Answer spread from site infection via tissue destruction and
lymph system
M. tuberculosis multiplication - Answer colonizes alveolar macrophages, replicating in
specialized vacuole or in cytosol
M. tuberculosis damage - Answer infection may elicit immune response which controls
infection of an immune response that destroys lung tissue
M. tuberculosis diagnosis - Answer culture and microscopy culture sputum, tuberculin
skin test, IFN gamma release test
describe primary infection of M. tuberculosis - Answer begins when contaminated
droplets reach alveoli of the lung,, binds to macrophage and is engulfed by alveolar
macrophages but hasn't been activated by a CD4 T cell therefore cannot digest M.
tuberculosis, M. tuberculosis establishes replicative vacuole, replicates inside
macrophage for 7-21 days, destroys macrophage, recruits macrophages T cell, natural
killer cell and dendritic cells to site of infection, dendritic cells process antigen and
present antigen to MHC I and MHC II proteins
what do CD8 cells with a TCR that recognizes M. tuberulosis antigen do? - Answer lyse
infected macrophages and dendritic cells, release IFn gamma which activated
macrophages
what do CD4 cells with a TCR that recognizes M. tuberulosis antigen do? - Answer
differentiate into Th2 and Th1 cells, Th1 release IFN gamma which activates
macrophages, Th1 release IL-2 and TNF alpha which recruit more T-cells, macrophages
and dendritic cells to site of infection
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