1. Transmembrane jadhesive jheterodimeric jproteins, jcomposed jof jan j jand ja jß jchain, jare
jexpressed jon jactivated jleukocytes jduring jinflammation. jThey jbind jprimarily jto
jintercellular jadhesion jmolecule j1 j(ICAM-1) jand jvascular jcell jadhesion jmolecule j1
j(VCAM-1), jboth jof jwhich jbelong jto jthe jfamily jof jproteins jknown jas
a. selectins
b. integrins
c. immunoglobulins
d. lectins
e. growth jfactors
ANS: jC, jSurface jproteins jexpressed jon jactivated jleukocytes jare jintegrins, jand jthey jbind
jto jintercellular jadhesion jmolecule j1 j(ICAM-1) jand jvascular jcell jadhesion jmolecule j1
j(VCAM- j1), jwhich jbelong jto jthe jimmunoglobulin jfamily jof jproteins.
2. Which j of j the j following j mediators j of j inflammation j has j chemotactic
j properties j and j is jincreased jin jpersons jtaking jaspirin?
a. Thromboxane jA2
b. Prostaglandin jE2
c. Platelet-activating jfactor
d. Leukotriene jB4
e. Interleukin-1
3. A j 2-year-old j child j known j to j suffer j from j recurrent j bacterial j infections j and j poor
j wound j healing j was j found j to j have j leukocyte j adhesion j molecule j deficiency
j 1 j (LAD-1). j The
,leukocytes jof jthis jpatient jdo jnot jexpress jCD18, ja jmolecule jclassified jas jbelonging jto jthe
jfamily jof
a. selectins
b. integrins
c. lectin jtype jof jvascular jadhesion jmolecules
d. aminotransferases
e. glycosidases
, Test jBank 2-2
ANS: jB, jLAD-1 jis jcharacterized jby ja jdeficiency jof jCD18, ja jcell jsurface jmolecule
jthat jis ja jß2 jintegrin. jThe jinfections joccur jbecause jthe jdefective jleukocytes jcannot
jadhere jto jendothelial jcells, jcannot jspread jand jattach, jand jcannot jphagocytose
jbacteria. jPBD7 j62
4. Bradykinin jis jproduced jfrom ja jhigh-molecular jweight j kininogen jcirculating jin jthe jblood.
This jreaction jis jmediated jby
a. coagulation jfactor jX
b. kallikrein
c. Hageman jfactor
d. complement j C3
e. protein jC
5. Nitric joxide jsynthesis jis jaugmented jin jendothelial jcells jby ja jcalmodulin-mediated
jinflux jof jwhich jelement?
a. Calcium
b. Sodium
c. Potassium
d. Oxygen
e. Nitrate
6. Which jof jthe jfollowing jmediators jof jinflammation jcauses jpain?
a. Nitric joxide
b. Complement jC3a
c. Bradykinin
d. Leukotriene jB4
e. Interleukin-1
ANS: j C, j Bradykinin j causes j pain. j Other j pain-causing j substances j are j substance
j P j and jprostaglandin jE2. jPBD7 j65
7. Aspirin jlowers jthe jbody jtemperature jby jinhibiting jthe jsynthesis jof jwhich jregulator jof
jthe jcentral jthermostat jin jthe jhypothalamus?
a. Leukotriene jB4
b. Lipoxin
c. Thromboxane jA2
d. Prostacyclin
e. Prostaglandin jE2
ANS: j E, j Aspirin jinhibits j the j action j of j cyclooxygenase, j and j thus j inhibits j the jsynthesis j of
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